HOOK3 (original) (raw)

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Protein-coding gene in the species Homo sapiens

HOOK3
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5J8E
Identifiers
Aliases	HOOK3, HK3, hook microtubule-tethering protein 3, hook microtubule tethering protein 3
External IDs	OMIM: 607825; MGI: 2443554; HomoloGene: 13022; GeneCards: HOOK3; OMA:HOOK3 - orthologs
Gene location (Human)Chr.Chromosome 8 (human)[1]Band8p11.21Start42,896,946 bp[1]End43,030,535 bp[1]
Gene location (Mouse)Chr.Chromosome 8 (mouse)[2]Band8|8 A2Start26,511,449 bp[2]End26,609,252 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inAchilles tendonsural nervetendon of biceps brachiiepithelium of colonpancreatic epithelial cellcorpus callosumendothelial cellbuccal mucosa cellinternal globus pallidusdeltoid muscleTop expressed inotolith organutricleknee jointtibialis anterior musclehandtriceps brachii musclevastus lateralis muscleRostral migratory streamtail of embryofootMore reference expression dataBioGPSn/a
Gene ontologyMolecular function microtubule binding protein binding identical protein binding dynein light intermediate chain binding dynactin binding dynein light chain binding dynein intermediate chain binding Cellular component HOPS complex FHF complex cis-Golgi network centriolar satellite microtubule cytoskeleton cytosol pericentriolar material cytoplasm Golgi apparatus centrosome Biological process endosome to lysosome transport endosome organization neuronal stem cell population maintenance Golgi localization early endosome to late endosome transport cytoplasmic microtubule organization protein transport lysosome organization microtubule anchoring at centrosome interkinetic nuclear migration negative regulation of neurogenesis protein localization to centrosome cytoskeleton-dependent intracellular transport Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez84376320191EnsemblENSG00000168172ENSMUSG00000037234UniProtQ86VS8Q8BUK6RefSeq (mRNA)NM_032410NM_207659RefSeq (protein)NP_115786NP_997542Location (UCSC)Chr 8: 42.9 – 43.03 MbChr 8: 26.51 – 26.61 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein Hook homolog 3 is a protein that in humans is encoded by the HOOK3 gene.[5][6]

Hook proteins are cytosolic coiled coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[6]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168172 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037234 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Kramer H, Phistry M (Mar 1999). "Genetic analysis of hook, a gene required for endocytic trafficking in drosophila". Genetics. 151 (2): 675–84. doi:10.1093/genetics/151.2.675. PMC 1460498. PMID 9927460.
6. ^ a b "Entrez Gene: HOOK3 hook homolog 3 (Drosophila)".

• Walenta JH, Didier AJ, Liu X, Krämer H (2001). "The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins". J. Cell Biol. 152 (5): 923–34. doi:10.1083/jcb.152.5.923. PMC 2198811. PMID 11238449.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shotland Y, Krämer H, Groisman EA (2003). "The Salmonella SpiC protein targets the mammalian Hook3 protein function to alter cellular trafficking". Mol. Microbiol. 49 (6): 1565–76. doi:10.1046/j.1365-2958.2003.03668.x. PMID 12950921. S2CID 30972454.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kaiser F, Kaufmann SH, Zerrahn J (2004). "IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3". J. Cell Sci. 117 (Pt 9): 1747–56. doi:10.1242/jcs.01039. PMID 15075236. S2CID 294834.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6): 442–58. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442. S2CID 25389776.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Sano H, Ishino M, Krämer H, et al. (2007). "The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A." J. Biol. Chem. 282 (11): 7973–81. doi:10.1074/jbc.M611537200. PMID 17237231.
• Ciampi R, Giordano TJ, Wikenheiser-Brokamp K, et al. (2007). "HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma". Endocr. Relat. Cancer. 14 (2): 445–52. doi:10.1677/ERC-07-0039. PMID 17639057.