IFT81 (original) (raw)

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IFT81
Identifiers
Aliases	IFT81, CDV-1, CDV-1R, CDV1, CDV1R, DV1, intraflagellar transport 81, SRTD19
External IDs	OMIM: 605489; MGI: 1098597; HomoloGene: 7664; GeneCards: IFT81; OMA:IFT81 - orthologs
Gene location (Human)Chr.Chromosome 12 (human)[1]Band12q24.11Start110,124,335 bp[1]End110,218,793 bp[1]
Gene location (Mouse)Chr.Chromosome 5 (mouse)[2]Band5 F|5 62.44 cMStart122,688,267 bp[2]End122,752,581 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inbronchial epithelial cellventricular zoneright uterine tubeganglionic eminenceAchilles tendonolfactory zone of nasal mucosatesticleEpithelium of choroid plexusleft testisright testisTop expressed inspermatidsacculespermatocyteneural layer of retinainterventricular septumgenital tubercleotic vesiclevestibular sensory epitheliumright ventricleolfactory epitheliumMore reference expression dataBioGPSn/a
Gene ontologyMolecular function tubulin binding protein binding Cellular component intraciliary transport particle B ciliary basal body centrosome sperm principal piece cell projection ciliary tip motile cilium sperm midpiece cilium Biological process cell projection organization spermatogenesis intraciliary transport intraciliary transport involved in cilium assembly cilium assembly regulation of smoothened signaling pathway Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez2898112589EnsemblENSG00000122970ENSMUSG00000029469UniProtQ8WYA0O35594RefSeq (mRNA)NM_001143779NM_014055NM_031473NM_001347946NM_001347947NM_001347948NM_009879NM_001358917NM_001358918NM_001358919RefSeq (protein)NP_001137251NP_054774NP_113661NP_001334875NP_001334876NP_001334877NP_001137251.1NP_054774.2NP_034009NP_001345846NP_001345847NP_001345848Location (UCSC)Chr 12: 110.12 – 110.22 MbChr 5: 122.69 – 122.75 MbPubMed search[3][4]
Wikidata
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Intraflagellar transport protein 81 homolog is a protein that in humans is encoded by the IFT81 gene.[5][6] Together with IFT74/72 it forms a core complex to build IFT particles[7] which are required for cilium formation. Additionally, it interacts with basal body components as CEP170[8] which regulates the disassembly of the cilium.

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122970 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029469 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: intraflagellar transport 81 homolog (Chlamydomonas)".
6. ^ Higashi M, Kobayashi K, Iijima M, Wakana S, Horiuchi M, Yasuda T, Yoshida G, Kanmura Y, Saheki T (December 2000). "Genomic organization and mapping of mouse CDV (carnitine deficiency-associated gene expressed in ventricle)-1 and its related CDV-1R gene". Mamm. Genome. 11 (12): 1053–7. doi:10.1007/s003350010207. PMID 11130971. S2CID 9319574.
7. ^ Lucker BF, Behal RH, Qin H, Siron LC, Taggart WD, Rosenbaum JL, Cole DG (July 2005). "Characterization of the intraflagellar transport complex B core: direct interaction of the IFT81 and IFT74/72 subunits". J. Biol. Chem. 280 (30): 27688–96. doi:10.1074/jbc.M505062200. PMID 15955805.
8. ^ Lamla, Stefan (2009). Functional characterisation of the centrosomal protein Cep170 (Thesis). LMU München: Faculty of Biology.

• Melzer D, Perry JR, Hernandez D, et al. (2008). Cheung VG (ed.). "A genome-wide association study identifies protein quantitative trait loci (pQTLs)". PLOS Genet. 4 (5): e1000072. doi:10.1371/journal.pgen.1000072. PMC 2362067. PMID 18464913.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Peng J, Yu L, Horiuchi M, et al. (2002). "Identification of human CDV-1R and mouse Cdv-1R, two novel proteins with putative signal peptides, especially highly expressed in testis and increased with the male sex maturation". Mol. Biol. Rep. 29 (4): 353–62. doi:10.1023/A:1021232518628. PMID 12549821. S2CID 908688.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.