IGSF8 (original) (raw)

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Protein-coding gene in the species Homo sapiens

IGSF8
Identifiers
Aliases IGSF8, CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL, immunoglobulin superfamily member 8
External IDs OMIM: 606644; MGI: 2154090; HomoloGene: 14163; GeneCards: IGSF8; OMA:IGSF8 - orthologs
Gene location (Human)Chromosome 1 (human)Chr.Chromosome 1 (human)[1]Chromosome 1 (human)Genomic location for IGSF8Genomic location for IGSF8Band1q23.2Start160,091,340 bp[1]End160,098,943 bp[1]
Gene location (Mouse)Chromosome 1 (mouse)Chr.Chromosome 1 (mouse)[2]Chromosome 1 (mouse)Genomic location for IGSF8Genomic location for IGSF8Band1 H3|1 79.59 cMStart172,089,208 bp[2]End172,147,408 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inright hemisphere of cerebellumright frontal lobeBrodmann area 9C1 segmentprefrontal cortexcingulate gyrusanterior cingulate cortexputamenHypothalamusnucleus accumbensTop expressed inventricular zoneprimary visual cortexsuperior frontal gyrusdorsomedial hypothalamic nucleusdentate gyrus of hippocampal formation granule cellsubiculumperirhinal cortexsuperior colliculusrespiratory epitheliumnasal epitheliumMore reference expression dataBioGPSn/a
Gene ontologyMolecular function protein binding Cellular component extracellular exosome membrane integral component of membrane plasma membrane Biological process skeletal muscle tissue development nervous system development cell population proliferation single fertilization cell motility Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez93185140559EnsemblENSG00000162729ENSMUSG00000038034UniProtQ969P0Q8R366RefSeq (mRNA)NM_001206665NM_052868NM_001320247NM_080419RefSeq (protein)NP_001193594NP_001307176NP_443100NP_536344Location (UCSC)Chr 1: 160.09 – 160.1 MbChr 1: 172.09 – 172.15 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene.[5][6][7] IGSF8 has also been designated as CD316 (cluster of differentiation 316). IGSF8 is an innate immune checkpoint that inhibits the cytotoxic activity of natural killer (NK) cells.[8] IGSF8 acts by binding to the Killer Ig-like Receptor KIR3DL2 (or, in mice, the analogous Klra9 receptor).[8] IGSF8 is frequently overexpressed relative to normal tissues in many cancers, included melanoma, urothelial carcinoma, and breast cancer,[8] and has been proposed as a potential therapeutic target in gliomas.[9] In normal tissues, IGSF8 is highly expressed in the brain, where it may contribute to the immune privilege of the central nervous system.[8]

IGSF8 as a Cancer Biomarker

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In gliomas, IGSF8 is strongly correlated with tumor grade and is a potential prognostic marker.[9] IGSF8 is enriched on ovarian cancer-derived extracellular vesicles and is a potential biomarker for the early detection of high grade serous ovarian cancer.[10]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162729 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038034 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Stipp CS, Kolesnikova TV, Hemler ME (Oct 2001). "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily". J Biol Chem. 276 (44): 40545–54. doi:10.1074/jbc.M107338200. PMID 11504738.
  6. ^ Clark KL, Zeng Z, Langford AL, Bowen SM, Todd SC (Oct 2001). "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins". J Immunol. 167 (9): 5115–21. doi:10.4049/jimmunol.167.9.5115. PMID 11673522.
  7. ^ "Entrez Gene: IGSF8 immunoglobulin superfamily, member 8".
  8. ^ a b c d Li, Yulong; Wu, Xiangyang; Sheng, Caibin; Liu, Hailing; Liu, Huizhu; Tang, Yixuan; Liu, Chao; Ding, Qingyang; Xie, Bin; Xiao, Xi; Zheng, Rongbin; Yu, Quan; Guo, Zengdan; Ma, Jian; Wang, Jin (May 2024). "IGSF8 is an innate immune checkpoint and cancer immunotherapy target". Cell. 187 (11): 2703–2716.e23. doi:10.1016/j.cell.2024.03.039. ISSN 0092-8674. PMID 38657602.
  9. ^ a b Ren, Jiaxing; Huang, Ping; Wang, Fei (September 2024). "IGSF8 is a potential target for the treatment of gliomas". Asian Journal of Surgery. 47 (9): 3883–3891. doi:10.1016/j.asjsur.2024.02.118.
  10. ^ Trinidad, Camille V.; Pathak, Harsh B.; Cheng, Shibo; Tzeng, Shin-Cheng; Madan, Rashna; Sardiu, Mihaela E.; Bantis, Leonidas E.; Deighan, Clayton; Jewell, Andrea; Rayamajhi, Sagar; Zeng, Yong; Godwin, Andrew K. (2023-10-26). "Lineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer". Scientific Reports. 13 (1): 18341. Bibcode:2023NatSR..1318341T. doi:10.1038/s41598-023-44050-5. ISSN 2045-2322. PMC 10603107. PMID 37884576.