Jacques Cohen (original) (raw)

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Dutch embryologist

Jacques Cohen
Born (1951-12-26) 26 December 1951 (age 72)The Hague, Netherlands
Nationality Netherlands Dutch
Alma mater Erasmus UniversityState University of Leiden
Known for reproductive medicinein-vitro fertilizationcryopreservation
Scientific career
Institutions University of CambridgeCornell UniversityReprogeneticsAlthea

Jacques Cohen (born December 26, 1951) is a Dutch embryologist based in New York, U.S. He is currently a Director at Reprogenetics LLC,[1][2] Laboratory Director at ART Institute of Washington at Walter Reed National Military Medical Center[3] (a joint fertility program with NIH), and Scientific Director of R & D at IVF-online[_citation needed_].

While working with Robert G. Edwards, he reported the freezing and successful thawing of a human blastocyst for in vitro fertilization[4] as the Senior Embryologist at Bourn Hall Clinic, Cambridge. At the same clinic, he developed methods to treat male factor infertility using in vitro fertilization (IVF). He also co-cultured human embryos with helper cells to promote growth.[5]

Cohen has been involved in the research of the application of micromanipulation techniques to operate on eggs, sperm and embryos. He has (co-)published papers on Intracytoplasmic Sperm Injection (ICSI)[6] and Assisted Hatching.[7]

As of October 2024, he is listed as an Emeritus Chief Editor at Reproductive Biomedicine Online.[8] He has also held faculty positions at Emory University, Cornell University Medical College, and the University of Connecticut.[_citation needed_]

Early Career and education

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Cohen was born in The Hague, Netherlands. In 1970, he went to the State University of Leiden, where he received a BSc degree in Biochemistry and subsequently an MSc degree in Reproductive physiology in 1978.[9] He attended the Erasmus University Rotterdam, where he obtained a PhD degree in Medicine in 1982, for his thesis named "Interaction between human spermatozoa and hamster oocytes".[10]

In 1982, Cohen joined Bourn Hall Clinic as an embryologist, working with Patrick Steptoe and Robert G. Edwards on techniques geared towards improving human conception through in vitro fertilization (IVF). Robert G. Edwards was the recipient of the Nobel prize for Medicine and Physiology in 2010. It was in Cambridge that Cohen first successfully froze and thawed a human blastocyst for use in IVF.[11]

Cohen also pioneered the use of micromanipulation techniques that are now widespread among embryologists. He developed a precursor technique of Intracytoplasmic Sperm Injection (ICSI), which is now used for treatment of nearly all male factor infertility diagnoses. Assisted Hatching (AH) is another commonly applied technique aimed at increasing implantation rates among infertile couples. Some of his work, such as cytoplasmic transfer, an attempt to boost development using the cytoplasm of donor eggs to supplement eggs from certain infertility patients, and single sperm freezing, has caused considerable ethical debate.[12]

  1. ^ Reprogenetics [1] Meet Our Team.
  2. ^ IVF.NET "Jacques Cohen - Embryo Selection" IVF.NET, 31 May 2009.
  3. ^ ART Institute of Washington - About Us [2] Archived 2012-04-25 at the Wayback Machine Jacques Cohen.
  4. ^ Cohen, Jacques; Simons, Roger F.; Edwards, Robert G.; Fehilly, Carole B.; Fishel, Simon B. (1985). "Pregnancies following the frozen storage of expanding human blastocysts". Journal of in Vitro Fertilization and Embryo Transfer. 2 (2): 59–64. doi:10.1007/BF01139337. PMID 4020239. S2CID 8187851.[_non-primary source needed_]
  5. ^ Lai, YM; Stein, DE; Soong, YK; Tang, YX; Grifo, J; Malter, HE; Talansky, BE; Cohen, J; et al. (1992). "Evaluation of Vero cell co-culture system for mouse embryos in various media". Human Reproduction. 7 (2): 276–80. doi:10.1093/oxfordjournals.humrep.a137632. PMID 1577944.[_non-primary source needed_]
  6. ^ Palermo, GD; Cohen, J; Alikani, M; Adler, A; Rosenwaks, Z (1995). "Intracytoplasmic sperm injection: A novel treatment for all forms of male factor infertility". Fertility and Sterility. 63 (6): 1231–40. doi:10.1016/S0015-0282(16)57603-1. PMID 7750593.[_non-primary source needed_]
  7. ^ Cohen, Jacques (1991). "Assisted hatching of human embryos". Journal of in Vitro Fertilization and Embryo Transfer. 8 (4): 179–90. doi:10.1007/BF01130802. PMID 1753162. S2CID 22604458.[_non-primary source needed_]
  8. ^ Reproductive Biomedicine Online Journal Info - Editorial Board
  9. ^ Jacques Cohen, Ph.D - website bestivf.org
  10. ^ Doctoral dissertation J. Cohen (Jacques): Interactie tussen menselijke zaadcellen en hamstereicellen - website of Erasmus University Rotterdam's institutional repository, RePub
  11. ^ Cohen, Jacques; Simons, Roger F.; Edwards, Robert G.; Fehilly, Carole B.; Fishel, Simon B. (1985-06-01). "Pregnancies following the frozen storage of expanding human blastocysts". Journal of in Vitro Fertilization and Embryo Transfer. 2 (2): 59–64. doi:10.1007/BF01139337. ISSN 1573-7330. PMID 4020239. S2CID 8187851.
  12. ^ Barritt, J. A.; Willadsen, S.; Brenner, C.; Cohen, J. (2001). "Cytoplasmic transfer in assisted reproduction". Human Reproduction Update. 7 (4): 428–35. doi:10.1093/humupd/7.4.428. PMID 11476356.