KCNQ5 (original) (raw)

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Protein-coding gene in the species Homo sapiens

KCNQ5
Identifiers
Aliases	KCNQ5, Kv7.5, potassium voltage-gated channel subfamily Q member 5, MRD46
External IDs	OMIM: 607357; MGI: 1924937; HomoloGene: 28270; GeneCards: KCNQ5; OMA:KCNQ5 - orthologs
Gene location (Human)Chr.Chromosome 6 (human)[1]Band6q13Start72,621,792 bp[1]End73,198,853 bp[1]
Gene location (Mouse)Chr.Chromosome 1 (mouse)[2]Band1|1 A4Start21,468,627 bp[2]End22,032,166 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inendothelial cellPonsBrodmann area 23tibialis anterior muscleSkeletal muscle tissue of rectus abdominisdeltoid musclequadriceps femoris muscleBrodmann area 46vastus lateralis musclesuperior frontal gyrusTop expressed inprimary motor cortexolfactory tuberclenucleus accumbenspiriform cortexsternocleidomastoid muscleprefrontal cortextemporal muscleglobus pallidusdigastric muscleTemporal LobeMore reference expression dataBioGPSn/a
Gene ontologyMolecular function ion channel activity potassium channel activity protein binding voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity calmodulin binding Cellular component membrane clathrin coat integral component of membrane integral component of plasma membrane voltage-gated potassium channel complex plasma membrane Biological process potassium ion transport regulation of ion transmembrane transport ion transport transmembrane transport potassium ion transmembrane transport Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez56479226922EnsemblENSG00000185760ENSMUSG00000028033UniProtQ9NR82Q9JK45RefSeq (mRNA)NM_001160130NM_001160132NM_001160133NM_001160134NM_019842NM_001160139NM_023872NM_001310477RefSeq (protein)NP_001153602NP_001153604NP_001153605NP_001153606NP_062816NP_001153611NP_001297406NP_076361Location (UCSC)Chr 6: 72.62 – 73.2 MbChr 1: 21.47 – 22.03 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium voltage-gated channel subfamily KQT member 5 is a protein that in humans is encoded by the KCNQ5 gene.[5][6][7][8]

This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of only one has been determined.[8]

KCNQ5 has been shown to interact with KvLQT3.[9]

• Voltage-gated potassium channel

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185760 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028033 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Lerche C, Scherer CR, Seebohm G, Derst C, Wei AD, Busch AE, Steinmeyer K (Aug 2000). "Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity". J Biol Chem. 275 (29): 22395–400. doi:10.1074/jbc.M002378200. PMID 10787416.
6. ^ Schroeder BC, Hechenberger M, Weinreich F, Kubisch C, Jentsch TJ (Sep 2000). "KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents". J Biol Chem. 275 (31): 24089–95. doi:10.1074/jbc.M003245200. PMID 10816588.
7. ^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
8. ^ a b "Entrez Gene: KCNQ5 potassium voltage-gated channel, KQT-like subfamily, member 5".
9. ^ Yus-Nájera, E; Muñoz A; Salvador N; Jensen B S; Rasmussen H B; Defelipe J; Villarroel A (2003). "Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation". Neuroscience. 120 (2): 353–64. doi:10.1016/S0306-4522(03)00321-X. ISSN 0306-4522. PMID 12890507. S2CID 38381189.

• Wickenden AD, Zou A, Wagoner PK, Jegla T (2001). "Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells". Br. J. Pharmacol. 132 (2): 381–4. doi:10.1038/sj.bjp.0703861. PMC 1572592. PMID 11159685.
• Yus-Najera E, Santana-Castro I, Villarroel A (2002). "The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels". J. Biol. Chem. 277 (32): 28545–53. doi:10.1074/jbc.M204130200. PMID 12032157.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ozeki Y, Tomoda T, Kleiderlein J, et al. (2003). "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth". Proc. Natl. Acad. Sci. U.S.A. 100 (1): 289–94. Bibcode:2003PNAS..100..289O. doi:10.1073/pnas.0136913100. PMC 140954. PMID 12506198.
• Yus-Nájera E, Muñoz A, Salvador N, et al. (2003). "Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation". Neuroscience. 120 (2): 353–64. doi:10.1016/S0306-4522(03)00321-X. PMID 12890507. S2CID 38381189.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Li Y, Langlais P, Gamper N, et al. (2004). "Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinase". J. Biol. Chem. 279 (44): 45399–407. doi:10.1074/jbc.M408410200. PMID 15304482.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Jensen HS, Grunnet M, Olesen SP (2007). "Inactivation as a new regulatory mechanism for neuronal Kv7 channels". Biophys. J. 92 (8): 2747–56. Bibcode:2007BpJ....92.2747J. doi:10.1529/biophysj.106.101287. PMC 1831682. PMID 17237198.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.