KRT33A (original) (raw)

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Protein-coding gene in the species Homo sapiens

KRT33A
Identifiers
Aliases	KRT33A, HA3I, Ha-3I, K33A, KRTHA3A, Krt1-3, hHa3-I, keratin 33A
External IDs	OMIM: 602761; MGI: 1919138; HomoloGene: 135742; GeneCards: KRT33A; OMA:KRT33A - orthologs
Gene location (Human)Chr.Chromosome 17 (human)[1]Band17q21.2Start41,346,092 bp[1]End41,350,828 bp[1]
Gene location (Mouse)Chr.Chromosome 11 (mouse)[2]Band11|11 DStart99,902,021 bp[2]End99,907,038 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed intesticlemucosa of esophagusleft testisright testisskin of abdomenvaginaskin of legminor salivary glandsright lungectocervixTop expressed inliphair follicleskin of backdermisskin of external earskin of abdomensexually immature organismmedial head of gastrocnemius muscleconjunctival fornixdiencephalonMore reference expression dataBioGPSn/a
Gene ontologyMolecular function structural molecule activity Cellular component intermediate filament extracellular space cytosol Biological process keratinization cornification Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez388371888EnsemblENSG00000261986ENSG00000006059ENSMUSG00000035592UniProtO76009Q8K0Y2RefSeq (mRNA)NM_004138NM_027983RefSeq (protein)NP_004129NP_082259Location (UCSC)Chr 17: 41.35 – 41.35 MbChr 11: 99.9 – 99.91 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Keratin, type I cuticular Ha3-I is a protein that in humans is encoded by the KRT33A gene.[5][6][7]

The protein encoded by this gene is a member of the keratin gene family. It is one of the type I hair keratin genes which are clustered in a region of chromosome 17q21.2 and have the same direction of transcription. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, KRT33A (this gene) and KRT33B.[7]

1. ^ a b c ENSG00000006059 GRCh38: Ensembl release 89: ENSG00000261986, ENSG00000006059 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035592 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^
6. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
7. ^ a b "Entrez Gene: KRT33A keratin 33A".

• Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S – 59S. doi:10.1111/1523-1747.ep12362635. PMID 7686952.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Rogers MA, Winter H, Langbein L, et al. (2005). "The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain". Differentiation. 72 (9–10): 527–40. doi:10.1111/j.1432-0436.2004.07209006.x. PMID 15617563.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.
• Rogers MA, Winter H, Wolf C, et al. (1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J. Biol. Chem. 273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID 9756910.