Kopexil (original) (raw)
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Kopexil
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| Names | |
| IUPAC names 2,3-Dihydro-3-hydroxy-2-imino-4-pyrimidinamine2,4-Diaminopyrimidine 3-_N_-oxide | |
| Other namesAminexil | |
| Identifiers | |
| CAS Number | 113275-13-1  Y74638-76-9 (pyridine oxide tautomer) Y |
| 3D model (JSmol) | Interactive image |
| ChemSpider | 10445922 |
| EC Number | 616-121-2 |
| PubChem CID | 10197687 |
| UNII | 1756681479 |
| CompTox Dashboard (EPA) | DTXSID40996155  |
| InChI InChI=1S/C4H6N4O/c5-3-1-2-7-4(6)8(3)9/h1-2H,5H2,(H2,6,7)Key: SGHQFNHCCOBUKB-UHFFFAOYSA-NInChI=1S/C4H6N4O/c5-3-1-2-7-4(6)8(3)9/h1-2,6,9H,5H2Key: YTKGAYFHUZTLCI-UHFFFAOYSA-N | |
| SMILES c1cnc([n+](c1N)[O-])N | |
| Properties | |
| Chemical formula | C4H6N4O |
| Molar mass | 126.119 g·mol−1 |
| Appearance | white odorless crystals[1] |
| Melting point | 210 to 218 °C (410 to 424 °F; 483 to 491 K)[1] |
| Solubility in water | slightly soluble[1] |
| Hazards | |
| GHS labelling: | |
| Pictograms |  |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264, P270, P301+P312, P330, P501 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).  Y verify (what is Y N ?) Infobox references |
Chemical compound
Kopexil (INCI name diaminopyrimidine oxide, trade name Aminexil) is a chemical compound similar to minoxidil. Minoxidil was originally used to treat high blood pressure; a side effect was increased body hair. Both compounds have been used for therapy of alopecia.[2] Kopexil is not approved for use as a drug in the United States or in Europe.
Kopexil is an _N_-oxide, a group of substances in which the nitrogen atom of a tertiary amine is oxidized. The compound can exist in two tautomeric forms.
Mechanism of action
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The exact mechanism of action of kopexil is unknown. There is no proof of therapeutic effect for kopexil against alopecia.[3]
- ^ a b c MSDS for Kopexil at Kumar Organics. Archived 2015-07-22 at the Wayback Machine March 28th 2012.
- ^ Trüeb RM, de Viragh PA: Status of scalp hair and therapy of alopecia in men in Switzerland; PMID 11256223.
- ^ Wolfgang Raab: Haarerkrankungen in der dermatologischen Praxis, p. 82, at Google Books (German).