L1TD1 (original) (raw)

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Protein-coding gene in the species Homo sapiens

L1TD1
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LR6, 3SOO
Identifiers
Aliases L1TD1, ECAT11, LINE-1 type transposase domain containing 1, LINE1 type transposase domain containing 1
External IDs MGI: 3578435; HomoloGene: 136289; GeneCards: L1TD1; OMA:L1TD1 - orthologs
Gene location (Human)Chromosome 1 (human)Chr.Chromosome 1 (human)[1]Chromosome 1 (human)Genomic location for L1TD1Genomic location for L1TD1Band1p31.3Start62,194,849 bp[1]End62,212,328 bp[1]
Gene location (Mouse)Chromosome 4 (mouse)Chr.Chromosome 4 (mouse)[2]Chromosome 4 (mouse)Genomic location for L1TD1Genomic location for L1TD1Band4|4 C6Start98,614,971 bp[2]End98,626,717 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed ingonadtesticleplacentaappendixmucosa of transverse colonwhite blood cellmonocyteright testisleft testisepithelium of colonTop expressed inyolk sacepiblastembryoblastocystblastocystprimitive streakmorulaembryotail of embryohandMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function single-stranded RNA binding protein binding Cellular component ribonucleoprotein complex Biological process transposition, RNA-mediated Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez54596381591EnsemblENSG00000240563ENSMUSG00000087166UniProtQ5T7N2Q587J6RefSeq (mRNA)NM_019079NM_001164835NM_001081202RefSeq (protein)NP_001158307NP_061952NP_001074671Location (UCSC)Chr 1: 62.19 – 62.21 MbChr 4: 98.61 – 98.63 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LINE-1 type transposase domain containing 1, also known as L1TD1, is an RNA-binding protein that involved with self-renewal of undifferentiated human embryonic stem cells and cancer cell proliferation. L1TD1 has been reported to associate with the development of several cancers.[5] [6] [7] [8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000240563 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000087166 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Iwabuchi KA, Yamakawa T, Sato Y, Ichisaka T, Takahashi K, Okita K, Yamanaka S (May 2011). "ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency". PLOS ONE. 6 (5): e20461. Bibcode:2011PLoSO...620461I. doi:10.1371/journal.pone.0020461. PMC 3102727. PMID 21637830.
  6. ^ Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R (March 2012). "RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation". Stem Cells. 30 (3): 452–60. doi:10.1002/stem.1013. PMC 3507993. PMID 22162396.
  7. ^ Wong RC, Ibrahim A, Fong H, Thompson N, Lock LF, Donovan PJ (April 2011). "L1TD1 is a marker for undifferentiated human embryonic stem cells". PLOS ONE. 6 (4): e19355. Bibcode:2011PLoSO...619355W. doi:10.1371/journal.pone.0019355. PMC 3084827. PMID 21559406.
  8. ^ Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y (October 2008). "LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis". Cancer Epidemiol Biomarkers Prev. 17 (10): 2555–64. doi:10.1158/1055-9965.EPI-08-0112. PMID 18842996. S2CID 24719399.