MAN1B1 (original) (raw)

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Protein-coding gene in the species Homo sapiens

MAN1B1
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1FMI, 1FO2, 1FO3, 1X9D
Identifiers
Aliases	MAN1B1, ERMAN1, MANA-ER, MRT15, ERManI, mannosidase alpha class 1B member 1
External IDs	OMIM: 604346; MGI: 2684954; HomoloGene: 5230; GeneCards: MAN1B1; OMA:MAN1B1 - orthologs
Gene location (Human)Chr.Chromosome 9 (human)[1]Band9q34.3Start137,086,857 bp[1]End137,109,189 bp[1]
Gene location (Mouse)Chr.Chromosome 2 (mouse)[2]Band2|2 A3Start25,222,350 bp[2]End25,242,224 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed instromal cell of endometriumright uterine tubeskin of leganterior pituitaryapex of heartskin of abdomenright hemisphere of cerebellumminor salivary glandsolfactory zone of nasal mucosaright lobe of thyroid glandTop expressed inspermatocyteIleal epitheliumspermatidneural layer of retinayolk saccorneal stromagranulocyteventricular zonedentate gyrus of hippocampal formation granule cellsuperior frontal gyrusMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function metal ion binding calcium ion binding hydrolase activity, acting on glycosyl bonds hydrolase activity mannosyl-oligosaccharide 1,2-alpha-mannosidase activity catalytic activity Cellular component extracellular vesicle integral component of membrane Golgi apparatus membrane endoplasmic reticulum membrane endoplasmic reticulum endoplasmic reticulum quality control compartment Golgi membrane Biological process oligosaccharide metabolic process metabolism N-glycan processing mannose trimming involved in glycoprotein ERAD pathway protein alpha-1,2-demannosylation protein glycosylation ubiquitin-dependent ERAD pathway trimming of terminal mannose on B branch trimming of terminal mannose on C branch trimming of first mannose on A branch trimming of second mannose on A branch endoplasmic reticulum mannose trimming Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez11253227619EnsemblENSG00000177239ENSMUSG00000036646UniProtQ9UKM7A2AJ15RefSeq (mRNA)NM_016219NM_001029983RefSeq (protein)NP_057303NP_001025154Location (UCSC)Chr 9: 137.09 – 137.11 MbChr 2: 25.22 – 25.24 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase is an enzyme that in humans is encoded by the MAN1B1 gene.[5][6][7]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177239 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036646 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Gonzalez DS, Karaveg K, Vandersall-Nairn AS, Lal A, Moremen KW (Aug 1999). "Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis". J Biol Chem. 274 (30): 21375–86. doi:10.1074/jbc.274.30.21375. PMID 10409699.
6. ^ Tremblay LO, Herscovics A (Nov 1999). "Cloning and expression of a specific human alpha 1,2-mannosidase that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan biosynthesis". Glycobiology. 9 (10): 1073–8. doi:10.1093/glycob/9.10.1073. PMID 10521544.
7. ^ "Entrez Gene: MAN1B1 mannosidase, alpha, class 1B, member 1".

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