MPPF (original) (raw)
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MPPF
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| Names | |
| Preferred IUPAC name 4-Fluoro-_N_-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-_N_-(pyridin-2-yl)benzamide | |
| Identifiers | |
| CAS Number | 155204-26-5  Y |
| 3D model (JSmol) | Interactive image |
| ChemSpider | 5036223  N |
| IUPHAR/BPS | 81 |
| PubChem CID | 6603915 |
| UNII | 81KHI46E5L Y |
| CompTox Dashboard (EPA) | DTXSID20424966  |
| InChI InChI=1S/C25H27FN4O2/c1-32-23-7-3-2-6-22(23)29-17-14-28(15-18-29)16-19-30(24-8-4-5-13-27-24)25(31)20-9-11-21(26)12-10-20/h2-13H,14-19H2,1H3 NKey: YJZYDPRMWYWYCG-UHFFFAOYSA-N NInChI=1/C25H27FN4O2/c1-32-23-7-3-2-6-22(23)29-17-14-28(15-18-29)16-19-30(24-8-4-5-13-27-24)25(31)20-9-11-21(26)12-10-20/h2-13H,14-19H2,1H3Key: YJZYDPRMWYWYCG-UHFFFAOYAQ |
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| SMILES COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4=CC=C(C=C4)F | |
| Properties | |
| Chemical formula | C25H27FN4O2 |
| Molar mass | 434.51 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).  N verify (what is YN ?) Infobox references |
Chemical compound
MPPF, with the full name 2'-methoxyphenyl-(_N_-2'-pyridinyl)-_p_-fluoro-benzamidoethyipiperazine, is a compound that binds to the serotonin-1A receptor. Labeled with fluorine-18 it has been used as a radioligand with positron emission tomography.[1]It has, e.g., been used to examine the difference in neuroreceptor binding in the human brain across sex and age.[2]
- ^ D. Le Bars (May 1998). "High-Yield Radiosynthesis and Preliminary In Vivo Evaluation of p-18FMPPF, a Fluoro Analog of WAY-100635". Nuclear Medicine and Biology. 25 (4): 343–350. doi:10.1016/S0969-8051(97)00229-1. PMID 9639295.
- ^ Nicolas Costes; Merlet, I; Ostrowsky, K; Faillenot, I; Lavenne, F; Zimmer, L; Ryvlin, P; Le Bars, D (December 2005). "A18F-MPPF PET normative database of 5-HT1A receptor binding in men and women over aging". The Journal of Nuclear Medicine. 46 (12): 1980–1989. PMID 16330560.