Mitochondrial ribosomal protein L13 (original) (raw)
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Protein-coding gene in the species Homo sapiens
| MRPL13 | |
|---|---|
| Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3J7Y, 3J9M | |
| Identifiers | |
| Aliases | MRPL13, L13, L13A, L13mt, RPL13, RPML13, mitochondrial ribosomal protein L13 |
| External IDs | OMIM: 610200; MGI: 2137218; HomoloGene: 90894; GeneCards: MRPL13; OMA:MRPL13 - orthologs |
Gene location (Human) Chr.Chromosome 8 (human)[1]   Band8q24.12Start120,380,761 bp[1]End120,445,402 bp[1] |
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Gene location (Mouse) Chr.Chromosome 15 (mouse)[2] Band15|15 D1Start55,397,490 bp[2]End55,421,144 bp[2] |
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| RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inmucosa of transverse colonganglionic eminenceventricular zoneright adrenal glandright adrenal cortexislet of Langerhansrectumstromal cell of endometriumleft adrenal glandleft adrenal cortexTop expressed inmedial ganglionic eminencemaxillary prominencemandibular prominenceintercostal muscleGonadal ridgeexternal carotid arteryinternal carotid arteryright ventriclefetal liver hematopoietic progenitor celldigastric muscleMore reference expression dataBioGPSn/a | |
| Gene ontologyMolecular function structural constituent of ribosome protein binding mRNA binding RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrial ribosome mitochondrion mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis negative regulation of translation Sources:Amigo / QuickGO | |
| OrthologsSpeciesHuman MouseEntrez2899868537EnsemblENSG00000172172ENSMUSG00000022370UniProtQ9BYD1Q9D1P0RefSeq (mRNA)NM_014078NM_026759RefSeq (protein)NP_054797NP_081035Location (UCSC)Chr 8: 120.38 – 120.45 MbChr 15: 55.4 – 55.42 MbPubMed search[3][4] | |
| Wikidata | |
| View/Edit HumanView/Edit Mouse |
Mitochondrial ribosomal protein L13 is a protein that in humans is encoded by the MRPL13 gene.[5]
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and play a crucial role in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) are composed of a small 28S subunit and a large 39S subunit, with an estimated protein to rRNA composition of 75% with contrasts with prokaryotic ribosomes, where this ratio is reversed. Another distinction between mammalian mitoribosomes and prokaryotic ribosomes is that the latter includes a 5S rRNA. The proteins that make up the mitoribosome vary significantly in sequence, and sometimes in biochemical properties across different species, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.
- ^ a b c GRCh38: Ensembl release 89: ENSG00000172172 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022370 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Mitochondrial ribosomal protein L13". Retrieved 2017-07-05.
- Mukhopadhyay R, Ray PS, Arif A, Brady AK, Kinter M, Fox PL (2008). "DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression". Mol. Cell. 32 (3): 371–82. doi:10.1016/j.molcel.2008.09.019. PMC 2644327. PMID 18995835.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.