NFIL3 (original) (raw)

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Protein-coding gene in the species Homo sapiens

NFIL3
Identifiers
Aliases NFIL3, E4BP4, IL3BP1, NF-IL3A, NFIL3A, nuclear factor, interleukin 3 regulated
External IDs OMIM: 605327; MGI: 109495; HomoloGene: 3928; GeneCards: NFIL3; OMA:NFIL3 - orthologs
Gene location (Human)Chromosome 9 (human)Chr.Chromosome 9 (human)[1]Chromosome 9 (human)Genomic location for NFIL3Genomic location for NFIL3Band9q22.31Start91,409,045 bp[1]End91,423,832 bp[1]
Gene location (Mouse)Chromosome 13 (mouse)Chr.Chromosome 13 (mouse)[2]Chromosome 13 (mouse)Genomic location for NFIL3Genomic location for NFIL3Band13 B1|13 27.68 cMStart53,121,245 bp[2]End53,135,109 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed invena cavapericardiumgastric mucosaleft uterine tubecartilage tissuepopliteal arterytibial arteriesstromal cell of endometriumperiodontal fiberright ventricleTop expressed inmuscle of thighgastrulagranulocytezygoteprimary oocytesecondary oocytedigastric muscleleft lobe of liverplantaris musclesternocleidomastoid muscleMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function DNA-binding transcription factor activity DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding protein binding transcription corepressor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific identical protein binding Cellular component nucleus Biological process cellular response to interleukin-4 positive regulation of gene expression regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II circadian rhythm immune response transcription, DNA-templated rhythmic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez478318030EnsemblENSG00000165030ENSMUSG00000056749UniProtQ16649O08750RefSeq (mRNA)NM_005384NM_001289999NM_001290000NM_017373RefSeq (protein)NP_001276928NP_001276929NP_005375NP_059069Location (UCSC)Chr 9: 91.41 – 91.42 MbChr 13: 53.12 – 53.14 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear factor, interleukin 3 regulated, also known as NFIL3 or E4BP4 is a protein which in humans is encoded by the NFIL3 gene.[5]

Expression of interleukin-3 (IL-3) is restricted to activated T cells, natural killer (NK) cells, and mast cell lines. Transcription initiation depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site.[5][6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165030 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056749 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: NFIL3 nuclear factor, interleukin 3 regulated".
  6. ^ Zhang W, Zhang J, Kornuc M, Kwan K, Frank R, Nimer SD (November 1995). "Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter". Molecular and Cellular Biology. 15 (11): 6055–63. doi:10.1128/mcb.15.11.6055. PMC 230857. PMID 7565758.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.