NME4 (original) (raw)

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Protein-coding gene in the species Homo sapiens

NME4
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1EHW
Identifiers
Aliases NME4, NDPK-D, NM23H4, nm23-H4, NME/NM23 nucleoside diphosphate kinase 4
External IDs OMIM: 601818; MGI: 1931148; HomoloGene: 3673; GeneCards: NME4; OMA:NME4 - orthologs
Gene location (Human)Chromosome 16 (human)Chr.Chromosome 16 (human)[1]Chromosome 16 (human)Genomic location for NME4Genomic location for NME4Band16p13.3Start396,725 bp[1]End410,367 bp[1]
Gene location (Mouse)Chromosome 17 (mouse)Chr.Chromosome 17 (mouse)[2]Chromosome 17 (mouse)Genomic location for NME4Genomic location for NME4Band17|17 A3.3Start26,310,708 bp[2]End26,314,576 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed instromal cell of endometriummuscle layer of sigmoid colonright adrenal cortexgastric mucosaleft adrenal cortexsaphenous veinventricular zoneleft uterine tubeleft coronary arteryright lobe of liverTop expressed inembryoembryoepiblastventricular zonegenital tubercletail of embryoyolk sacmaxillary prominencemandibular prominencefetal liver hematopoietic progenitor cellMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function metal ion binding lipid binding nucleotide binding transferase activity kinase activity ATP binding protein binding nucleoside diphosphate kinase activity cardiolipin binding Cellular component mitochondrial matrix membrane mitochondrial inner membrane mitochondrion intracellular anatomical structure mitochondrial intermembrane space Biological process nucleobase-containing small molecule interconversion nucleoside metabolic process nucleoside diphosphate phosphorylation GTP biosynthetic process UTP biosynthetic process CTP biosynthetic process nucleotide metabolic process phosphorylation regulation of apoptotic process lipid transport Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez483356520EnsemblENSG00000103202ENSMUSG00000024177UniProtO00746Q9WV84RefSeq (mRNA)NM_005009NM_001286433NM_001286435NM_001286436NM_001286438NM_001286439NM_001286440NM_019731RefSeq (protein)NP_001273362NP_001273364NP_001273365NP_001273367NP_001273368NP_001273369NP_005000NP_062705Location (UCSC)Chr 16: 0.4 – 0.41 MbChr 17: 26.31 – 26.31 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Non-metastatic cells 4, protein expressed in, also known as NME4, is a protein which in humans is encoded by the NME4 gene.[5][6]

The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4. The first nm23 gene, nm23-H1 (NME1), was isolated based on its reduced expression in a highly metastatic murine melanoma cell line and was proposed to be a metastasis suppressing gene. The human equivalent was obtained by cDNA library screening using the murine gene as a probe and found to be homologous to the Drosophila awd gene. A second human gene, nm23-H2 (NME2), encoding a protein 88% identical to nm23-H1, was subsequently isolated. Both genes were localized on 17q21.3 and their gene products were formerly identified as the A and B subunits of NDP kinases. In mammals, functional NDP kinases are heterohexamers of the A and B monomers, which can combine at variable ratios to form different types of hybrids.[6] These enzymes are highly expressed in tumors as compared with normal tissues. In some cell lines and in certain solid tumors, decreased expression of NME1 is associated with increased metastatic potential; moreover, when transfected into very aggressive cell lines, such as human breast carcinoma, NME1 decreased the metastatic potential. A third human gene, DR-nm23 (NME3), was identified and found to share high sequence similarity with the NME1 and NME2 genes. It is highly expressed in blast crisis transition of chronic myeloid leukemia. When overexpressed by transfection, NME3 suppressed granulocyte differentiation and induced apoptosis of myeloid precursor cells.[5]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103202 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024177 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: NME4 non-metastatic cells 4, protein expressed in".
  6. ^ a b Milon L, Rousseau-Merck MF, Munier A, Erent M, Lascu I, Capeau J, Lacombe ML (Apr 1997). "nm23-H4, a new member of the family of human nm23/nucleoside diphosphate kinase genes localised on chromosome 16p13". Human Genetics. 99 (4): 550–7. doi:10.1007/s004390050405. PMID 9099850. S2CID 8408840.