O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (original) (raw)
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Class of enzymes
| O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | |
|---|---|
| Identifiers | |
| EC no. | 2.4.1.222 |
| CAS no. | 299203-70-6 |
| Databases | |
| IntEnz | IntEnz view |
| BRENDA | BRENDA entry |
| ExPASy | NiceZyme view |
| KEGG | KEGG entry |
| MetaCyc | metabolic pathway |
| PRIAM | profile |
| PDB structures | RCSB PDB PDBe PDBsum |
| SearchPMCarticlesPubMedarticlesNCBIproteins |
In enzymology, an O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (EC 2.4.1.222) is an enzyme that catalyzes the chemical reaction in which a beta-D-GlcNAc residue is transferred from UDP-D-GlcNAc to the fucose residue of a fucosylated protein.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase. This enzyme is also called O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase. This enzyme participates in notch signaling pathway.
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2J0A and 2J0B.
- Stanley P, Irvine KD, Haltiwanger RS, Vogt TF (2000). "Fringe is a glycosyltransferase that modifies Notch". Nature. 406 (6794): 369–75. Bibcode:2000Natur.406..369M. doi:10.1038/35019000. PMID 10935626. S2CID 4382611.