OAS2 (original) (raw)

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Protein-coding gene in the species Homo sapiens

OAS2
Identifiers
Aliases OAS2, 2'-5'-oligoadenylate synthetase 2
External IDs OMIM: 603350; MGI: 2180852; HomoloGene: 49478; GeneCards: OAS2; OMA:OAS2 - orthologs
Gene location (Human)Chromosome 12 (human)Chr.Chromosome 12 (human)[1]Chromosome 12 (human)Genomic location for OAS2Genomic location for OAS2Band12q24.13Start112,978,395 bp[1]End113,011,723 bp[1]
Gene location (Mouse)Chromosome 5 (mouse)Chr.Chromosome 5 (mouse)[2]Chromosome 5 (mouse)Genomic location for OAS2Genomic location for OAS2Band5 F|5 60.64 cMStart120,868,398 bp[2]End120,887,918 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inmonocytegranulocytelymph nodedeciduaappendixgallbladderspleenright lungbloodolfactory zone of nasal mucosaTop expressed inmucous cell of stomachgranulocytestroma of bone marrowsubmandibular glandepithelium of stomachbloodgastrulamyocardium of ventriclesubcutaneous adipose tissuecervixMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function transferase activity nucleotide binding nucleotidyltransferase activity zinc ion binding metal ion binding 2'-5'-oligoadenylate synthetase activity protein binding RNA binding double-stranded RNA binding ATP binding Cellular component cytoplasm membrane endoplasmic reticulum mitochondrion perinuclear region of cytoplasm nucleus nucleoplasm cytosol intracellular membrane-bounded organelle Biological process purine nucleotide biosynthetic process interferon-gamma-mediated signaling pathway immune system process protein myristoylation response to virus RNA catabolic process protein glycosylation defense response to virus type I interferon signaling pathway immune response innate immune response nucleobase-containing compound metabolic process response to bacterium regulation of ribonuclease activity regulation of lactation Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez4939246728EnsemblENSG00000111335ENSMUSG00000032690UniProtP29728E9Q9A9RefSeq (mRNA)NM_001032731NM_002535NM_016817NM_145227NM_001347448RefSeq (protein)NP_001027903NP_002526NP_058197NP_001334377NP_660262Location (UCSC)Chr 12: 112.98 – 113.01 MbChr 5: 120.87 – 120.89 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

2'-5'-oligoadenylate synthetase 2 is an enzyme that in humans is encoded by the OAS2 gene.[5][6]

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111335 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032690 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hovnanian A, Rebouillat D, Mattei MG, Levy ER, Marie I, Monaco AP, Hovanessian AG (Dec 1998). "The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms". Genomics. 52 (3): 267–277. doi:10.1006/geno.1998.5443. PMID 9790745.
  6. ^ a b "Entrez Gene: OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa".