RGS8 (original) (raw)

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Protein-coding gene in the species Homo sapiens

RGS8
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2IHD, 2ODE, 5DO9
Identifiers
Aliases	RGS8, regulator of G protein signaling 8
External IDs	OMIM: 607189; MGI: 108408; HomoloGene: 23152; GeneCards: RGS8; OMA:RGS8 - orthologs
Gene location (Human)Chr.Chromosome 1 (human)[1]Band1q25.3Start182,641,816 bp[1]End182,684,587 bp[1]
Gene location (Mouse)Chr.Chromosome 1 (mouse)[2]Band1 G3|1 65.41 cMStart153,528,771 bp[2]End153,576,069 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inlateral nuclear group of thalamusnucleus accumbensponsputamencaudate nucleuscerebellar vermistesticlegonadspermpars reticulataTop expressed inlobe of cerebellumcerebellar vermisneural layer of retinamedial geniculate nucleusmedial dorsal nucleussuperior colliculuslateral geniculate nucleusolfactory tubercleinferior colliculidentate gyrus of hippocampal formation granule cellMore reference expression dataBioGPSn/a
Gene ontologyMolecular function protein binding GTPase activator activity GTPase activity Cellular component cytoplasm extrinsic component of cytoplasmic side of plasma membrane neuronal cell body membrane perikaryon plasma membrane dendrite cell projection membrane nucleus Biological process G protein-coupled acetylcholine receptor signaling pathway regulation of dopamine receptor signaling pathway positive regulation of GTPase activity negative regulation of signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez8539767792EnsemblENSG00000135824ENSMUSG00000042671UniProtP57771Q8BXT1RefSeq (mRNA)NM_001102450NM_033345NM_001369564NM_001387847NM_001387848NM_001387849NM_026380NM_001347115NM_001357525RefSeq (protein)NP_001095920NP_203131NP_001356493NP_001334044NP_080656NP_001344454Location (UCSC)Chr 1: 182.64 – 182.68 MbChr 1: 153.53 – 153.58 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Regulator of G-protein signaling 8 is a protein that in humans is encoded by the RGS8 gene.[5][6]

This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation.[6]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135824 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042671 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, Morgenbesser SD, Su K, Faruque MU, Pinkett H, Graham C, Baxevanis AD, Klinger KW, Landes GM, Trent JM, Carpten JD (Apr 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
6. ^ a b "Entrez Gene: RGS8 regulator of G-protein signalling 8".

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• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
• Luo X, Popov S, Bera AK, Wilkie TM, Muallem S (2001). "RGS proteins provide biochemical control of agonist-evoked [Ca2+]i oscillations". Molecular Cell. 7 (3): 651–660. doi:10.1016/S1097-2765(01)00211-8. PMID 11463389.
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• Popov S, Yu K, Kozasa T, Wilkie TM (1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10 and GAIP retain GTPase activating protein activity in vitro". Proc Natl Acad Sci USA. 94 (14): 7216–20. Bibcode:1997PNAS...94.7216P. doi:10.1073/pnas.94.14.7216. PMC 23796. PMID 9207071.
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• Ross EM, Wilkie TM (2000). "GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins". Annual Review of Biochemistry. 69: 795–827. doi:10.1146/annurev.biochem.69.1.795. PMID 10966476.
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• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Masuho I, Itoh M, Itoh H, Saitoh O (2004). "The mechanism of membrane-translocation of regulator of G-protein signaling (RGS) 8 induced by Galpha expression". J. Neurochem. 88 (1): 161–8. doi:10.1046/j.1471-4159.2003.02139.x. PMID 14675160.
• Larminie C, Murdock P, Walhin JP, et al. (2004). "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system". Brain Res. Mol. Brain Res. 122 (1): 24–34. doi:10.1016/j.molbrainres.2003.11.014. PMID 14992813.
• Saitoh O, Yoshihiro K (2005). "Biochemical and Electrophysiological Analyses of RGS8 Function". Regulators of G-Protein Signaling, Part B. Methods in Enzymology. Vol. 390. pp. 129–48. doi:10.1016/S0076-6879(04)90009-2. ISBN 978-0-12-182795-3. PMID 15488175.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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• Benians A, Nobles M, Hosny S, Tinker A (2005). "Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics". J. Biol. Chem. 280 (14): 13383–94. doi:10.1074/jbc.M410163200. PMID 15677457.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
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