SLA2 (original) (raw)

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

SLA2
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4M4Z
Identifiers
Aliases	SLA2, C20orf156, MARS, SLAP-2, SLAP2, Src-like-adaptor 2, Src like adaptor 2
External IDs	OMIM: 606577; MGI: 1925049; HomoloGene: 49989; GeneCards: SLA2; OMA:SLA2 - orthologs
Gene location (Human)Chr.Chromosome 20 (human)[1]Band20q11.23Start36,612,318 bp[1]End36,646,196 bp[1]
Gene location (Mouse)Chr.Chromosome 2 (mouse)[2]Band2|2 H1Start156,714,377 bp[2]End156,729,112 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inbuccal mucosa cellgranulocytemonocytebloodtesticlelymph nodespleenappendixoocytebone marrow cellsTop expressed inthymuszygoteprimary oocytesecondary oocytegranulocyteembryobloodembryopharynxmorulaMore reference expression dataBioGPSn/a
Gene ontologyMolecular function protein binding protein N-terminus binding non-membrane spanning protein tyrosine kinase activity signaling receptor binding 1-phosphatidylinositol-3-kinase regulator activity Cellular component cytoplasm late endosome plasma membrane endosome membrane membrane cytoplasmic vesicle nucleoplasm Golgi apparatus intracellular membrane-bounded organelle extrinsic component of cytoplasmic side of plasma membrane phosphatidylinositol 3-kinase complex Biological process negative regulation of calcium-mediated signaling negative regulation of B cell activation intracellular receptor signaling pathway negative regulation of transcription by RNA polymerase II T cell activation B cell mediated immunity regulation of immune response antigen receptor-mediated signaling pathway positive regulation of signal transduction transmembrane receptor protein tyrosine kinase signaling pathway cell migration cell differentiation peptidyl-tyrosine autophosphorylation regulation of cell population proliferation innate immune response regulation of signal transduction regulation of phosphatidylinositol 3-kinase activity negative regulation of insulin receptor signaling pathway phosphatidylinositol phosphate biosynthetic process Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez8417477799EnsemblENSG00000101082ENSMUSG00000027636UniProtQ9H6Q3Q8R4L0RefSeq (mRNA)NM_032214NM_175077NM_029983NM_001356495RefSeq (protein)NP_115590NP_778252NP_084259NP_001343424Location (UCSC)Chr 20: 36.61 – 36.65 MbChr 2: 156.71 – 156.73 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Src-like-adapter 2 is a protein that in humans is encoded by the SLA2 gene.[5][6]

This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.[6]

SLA2 has been shown to interact with Cbl gene.[7]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101082 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027636 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Holland SJ, Liao XC, Mendenhall MK, Zhou X, Pardo J, Chu P, Spencer C, Fu A, Sheng N, Yu P, Pali E, Nagin A, Shen M, Yu S, Chan E, Wu X, Li C, Woisetschlager M, Aversa G, Kolbinger F, Bennett MK, Molineaux S, Luo Y, Payan DG, Mancebo HS, Wu J (Nov 2001). "Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling". J Exp Med. 194 (9): 1263–76. CiteSeerX 10.1.1.283.1429. doi:10.1084/jem.194.9.1263. PMC 2195979. PMID 11696592.
6. ^ a b "Entrez Gene: SLA2 Src-like-adaptor 2".
7. ^ Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O, Sawasdikosol S, Lodish HF, Mann M (May 2002). "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling". J. Biol. Chem. 277 (21): 19131–8. doi:10.1074/jbc.M110318200. PMID 11891219.

• Loreto MP, McGlade CJ (2003). "Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v". Oncogene. 22 (2): 266–73. doi:10.1038/sj.onc.1206114. PMID 12527895.
• Loreto MP, Berry DM, McGlade CJ (2002). "Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling". Mol. Cell. Biol. 22 (12): 4241–55. doi:10.1128/MCB.22.12.4241-4255.2002. PMC 133880. PMID 12024036.
• Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O, Sawasdikosol S, Lodish HF, Mann M (2002). "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling". J. Biol. Chem. 277 (21): 19131–8. doi:10.1074/jbc.M110318200. PMID 11891219.