Suloctidil (original) (raw)

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Chemical compound

Pharmaceutical compound

Suloctidil
Clinical data
ATC code C04AX19 (WHO)
Identifiers
IUPAC name 1-[4-(isopropylthio)phenyl]-2-(octylamino)propan-1-ol
CAS Number 54767-75-8 checkY
PubChem CID 5354
UNII XV1N1XY17K
ChEMBL ChEMBL588119
CompTox Dashboard (EPA) DTXSID701017974 DTXSID4045638, DTXSID701017974 Edit this at Wikidata
ECHA InfoCard 100.053.920 Edit this at Wikidata
Chemical and physical data
Formula C20H35NOS
Molar mass 337.57 g·mol−1
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Suloctidil was a sulfur-containing aminoalcohol that was brought to market in the early 1970s as a vasodilator by Continental Pharma, a Belgian company.[1]: 118–121 [2][3]

Continental was bought by Monsanto in 1984, primarily on the promise of sales of suloctidil, which was approved in Europe at the time, but not in the US.[4] However, in 1985 Monsanto halted development and withdrew the drug worldwide following reports of liver toxicity.[5]: 251

  1. ^ Hladovec J (1989). Antithrombotic Drugs in Thrombosis Models. CRC Press. ISBN 978-0-8493-5162-4.
  2. ^ Roncucci R, Roba J, Lambelin G, Ferenczi M, Blaton V, Vandamme D, Peeters H (March 1975). "Potential antilipolytic activity of suloctidil". Die Naturwissenschaften. 62 (3): 141–2. Bibcode:1975NW.....62..141R. doi:10.1007/bf00623284. PMID 1240601. S2CID 29484315.
  3. ^ BE granted 739678, Buu-Hoi NP, Lambelin G, Roba J, Jacques G, Gillet C, "1-Subst-phenyl-2-amino-ethanols useful as beta adrenergic agents peripheral vasodilators and hypotensive agents"
  4. ^ "Monsanto's $150 mil. Life Sciences Research Center". Pharma & Medteck Business Intelligence. 5 November 1984. Archived from the original on 2015-07-07.
  5. ^ "Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments Twelfth Issue: Pharmaceuticals" (PDF). Department of Economic and Social Affairs of the United Nations Secretariat. New York: United Nations. 2005.