Syntaxin 3 (original) (raw)

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Protein-coding gene in the species Homo sapiens

STX3
Identifiers
Aliases STX3, STX3A, Syntaxin 3, MVID2, RDMVID, DIAR12
External IDs OMIM: 600876; MGI: 103077; HomoloGene: 80191; GeneCards: STX3; OMA:STX3 - orthologs
Gene location (Human)Chromosome 11 (human)Chr.Chromosome 11 (human)[1]Chromosome 11 (human)Genomic location for STX3Genomic location for STX3Band11q12.1Start59,713,456 bp[1]End59,805,882 bp[1]
Gene location (Mouse)Chromosome 19 (mouse)Chr.Chromosome 19 (mouse)[2]Chromosome 19 (mouse)Genomic location for STX3Genomic location for STX3Band19|19 AStart11,752,482 bp[2]End11,796,767 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inrectumright lungbloodislet of Langerhansupper lobe of left lungduodenumgallbladderjejunal mucosamucosa of colonsecondary oocyteTop expressed inneural layer of retinaretinal pigment epitheliumciliary bodymedullary collecting ductepithelium of small intestineprimitive streakpineal glandirisintestinal villusileumMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function SNAP receptor activity protein binding arachidonic acid binding SNARE binding Cellular component integral component of membrane membrane cell-cell junction growth cone secretory granule vacuole dendrite SNARE complex azurophil granule specific granule apical plasma membrane neuron projection extracellular exosome lamellipodium photoreceptor cell terminal bouton ribbon synapse synaptic vesicle presynaptic membrane melanosome zymogen granule membrane plasma membrane postsynapse endomembrane system presynaptic active zone membrane Schaffer collateral - CA1 synapse glutamatergic synapse Biological process synaptic vesicle docking synaptic vesicle fusion to presynaptic active zone membrane membrane fusion vesicle docking positive regulation of protein localization to plasma membrane positive regulation of chemotaxis positive regulation of cell population proliferation positive regulation of protein localization to cell surface intracellular protein transport neurotransmitter transport neuron projection development vesicle-mediated transport positive regulation of cell adhesion long-term potentiation exocytosis vesicle fusion exocytic insertion of neurotransmitter receptor to postsynaptic membrane transport cytokine-mediated signaling pathway vesicle-mediated transport in synapse Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez680920908EnsemblENSG00000166900ENSMUSG00000041488UniProtQ13277Q64704RefSeq (mRNA)NM_001178040NM_004177NM_001025307NM_001025308NM_001286543NM_011502NM_152220NM_001360386RefSeq (protein)NP_001171511NP_004168NP_001020478NP_001273472NP_035632NP_689344NP_001347315Location (UCSC)Chr 11: 59.71 – 59.81 MbChr 19: 11.75 – 11.8 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Syntaxin 3, also known as STX3, is a protein[5] which in humans is encoded by the STX3 gene.[6][7]

The protein encoded by this gene is a member of the syntaxin family of cellular receptors for transport vesicles which participate in exocytosis in neutrophils.[6] STX3 has an important role in the growth of neurites and serves as a direct target for omega-6 arachidonic acid.[8]Mutations in Syntaxin 3 cause Microvillus inclusion disease.[9]

Syntaxin 3 has been shown to interact with SNAP-25,[10][11][12] SNAP23[11][12][13][14] and SNAP29.[12]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166900 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041488 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ibaraki K, Horikawa HP, Morita T, Mori H, Sakimura K, Mishina M, Saisu H, Abe T (June 1995). "Identification of four different forms of syntaxin 3". Biochem. Biophys. Res. Commun. 211 (3): 997–1005. doi:10.1006/bbrc.1995.1910. PMID 7598732.
  6. ^ a b Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F (March 1999). "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1". J. Leukoc. Biol. 65 (3): 397–406. doi:10.1002/jlb.65.3.397. hdl:10261/59829. PMID 10080545. S2CID 18988377. Archived from the original on 2005-02-27. Retrieved 2008-08-13.
  7. ^ "Entrez Gene: STX3 syntaxin 3".
  8. ^ Darios F, Davletov B (April 2006). "Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3". Nature. 440 (7085): 813–7. Bibcode:2006Natur.440..813D. doi:10.1038/nature04598. PMID 16598260. S2CID 4411524.
  9. ^ Wiegerinck CL, Janecke AR, Schneeberger K, Vogel GF, van Haaften-Visser DY, Escher JC, Adam R, Thöni CE, Pfaller K, Jordan AJ, Weis CA, Nijman IJ, Monroe GR, van Hasselt PM, Cutz E, Klumperman J, Clevers H, Nieuwenhuis EE, Houwen RH, van Haaften G, Hess MW, Huber LA, Stapelbroek JM, Müller T, Middendorp S (2014). "Loss of syntaxin 3 causes variant microvillus inclusion disease". Gastroenterology. 147 (1): 65–68.e10. doi:10.1053/j.gastro.2014.04.002. PMID 24726755.
  10. ^ Hata Y, Südhof TC (Jun 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.
  11. ^ a b Ravichandran V, Chawla A, Roche PA (Jun 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". J. Biol. Chem. 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. PMID 8663154.
  12. ^ a b c Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (Dec 1998). "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
  13. ^ Imai A, Nashida T, Yoshie S, Shimomura H (Aug 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Arch. Oral Biol. 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. PMID 12828989.
  14. ^ Araki S, Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H, Niki T, Okazawa H, Kubota T, Kasuga M (May 1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochem. Biophys. Res. Commun. 234 (1): 257–62. doi:10.1006/bbrc.1997.6560. hdl:20.500.14094/D2002245. PMID 9168999.