TENC1 (original) (raw)

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Protein-coding gene in the species Homo sapiens

TNS2
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2DKQ, 2KNO, 2L6K, 2LOZ, 3HQC
Identifiers
Aliases	TNS2, C1-TEN, C1TEN, TENC1, tensin 2
External IDs	OMIM: 607717; MGI: 2387586; HomoloGene: 37077; GeneCards: TNS2; OMA:TNS2 - orthologs
Gene location (Human)Chr.Chromosome 12 (human)[1]Band12q13.13Start53,046,969 bp[1]End53,064,379 bp[1]
Gene location (Mouse)Chr.Chromosome 15 (mouse)[2]Band15 F2|15 57.29 cMStart102,008,848 bp[2]End102,024,836 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inapex of heartgastric mucosatibial nervecanal of the cervixright ovaryleft uterine tubebody of uterusleft ovaryright lungright lobe of thyroid glandTop expressed inankle jointmuscle of thightunica media of zone of aortaright lungright lung lobelipbrown adipose tissuemyocardium of ventricleankleleft lungMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function kinase binding phosphoprotein phosphatase activity protein binding hydrolase activity metal ion binding Cellular component cell junction plasma membrane intracellular anatomical structure membrane focal adhesion Biological process protein dephosphorylation collagen metabolic process intracellular signal transduction multicellular organismal homeostasis response to muscle activity cellular homeostasis kidney development negative regulation of cell population proliferation multicellular organism growth Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez23371209039EnsemblENSG00000111077ENSMUSG00000037003UniProtQ63HR2Q8CGB6RefSeq (mRNA)NM_015319NM_170754NM_198316NM_153533NM_001355636RefSeq (protein)NP_056134NP_736610NP_938072NP_705761NP_001342565Location (UCSC)Chr 12: 53.05 – 53.06 MbChr 15: 102.01 – 102.02 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tensin-like C1 domain-containing phosphatase is an enzyme that in humans is encoded by the TENC1 gene.[5]

The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[5]

TENC1 has been shown to interact with AXL receptor tyrosine kinase.[6]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111077 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037003 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ a b "Entrez Gene: TENC1 tensin like C1 domain containing phosphatase (tensin 2)".
6. ^ Hafizi, Sassan; Alindri Filiz; Karlsson Roger; Dahlbäck Björn (Dec 2002). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. 299 (5). United States: 793–800. doi:10.1016/S0006-291X(02)02718-3. ISSN 0006-291X. PMID 12470648.

• Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.

• Chen H, Duncan IC, Bozorgchami H, Lo SH (2002). "Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 733–8. Bibcode:2002PNAS...99..733C. doi:10.1073/pnas.022518699. PMC 117374. PMID 11792844.

• Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2003). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. 299 (5): 793–800. doi:10.1016/S0006-291X(02)02718-3. PMID 12470648.

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

• Calderwood DA, Fujioka Y, de Pereda JM, et al. (2003). "Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2272–7. Bibcode:2003PNAS..100.2272C. doi:10.1073/pnas.262791999. PMC 151330. PMID 12606711.

• Hu Y, Fang X, Dunham SM, et al. (2004). "90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling". J. Biol. Chem. 279 (28): 29325–35. doi:10.1074/jbc.M311144200. PMID 15117958.

• Hafizi S, Ibraimi F, Dahlbäck B (2006). "C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration". FASEB J. 19 (8): 971–3. doi:10.1096/fj.04-2532fje. PMID 15817639. S2CID 42601912.

• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

• Yam JW, Ko FC, Chan CY, et al. (2006). "Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma". Hepatology. 44 (4): 881–90. doi:10.1002/hep.21339. PMID 17006924. S2CID 10376927.

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Tensin-2