TNP2 (original) (raw)

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Protein-coding gene in the species Homo sapiens

TNP2
Identifiers
Aliases	TNP2, TP2, transition protein 2 (during histone to protamine replacement), transition protein 2
External IDs	OMIM: 190232; MGI: 98785; HomoloGene: 3958; GeneCards: TNP2; OMA:TNP2 - orthologs
Gene location (Human)Chr.Chromosome 16 (human)[1]Band16p13.13Start11,267,748 bp[1]End11,269,533 bp[1]
Gene location (Mouse)Chr.Chromosome 16 (mouse)[2]Band16 A1|16 5.83 cMStart10,605,800 bp[2]End10,606,524 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inspermleft testistesticleright testisgonadright coronary arteryhuman musculoskeletal systemmuscular systemmusclemuscleTop expressed inseminiferous tubulespermatidspermatocyteembryomorulamorulablastocystskeletal muscle tissuecentral gray substance of midbrainnucleus of stria terminalisMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function DNA binding metal ion binding zinc ion binding Cellular component male germ cell nucleus nucleosome nucleus chromosome Biological process multicellular organism development cell differentiation spermatogenesis acrosome reaction penetration of zona pellucida positive regulation of protein processing Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez714221959EnsemblENSG00000178279ENSMUSG00000043050UniProtQ05952P11378RefSeq (mRNA)NM_005425NM_013694RefSeq (protein)NP_005416NP_038722Location (UCSC)Chr 16: 11.27 – 11.27 MbChr 16: 10.61 – 10.61 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear transition protein 2 is a protein that in humans is encoded by the TNP2 gene.[5][6][7]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178279 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043050 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Engel W, Keime S, Kremling H, Hameister H, Schluter G (Nov 1992). "The genes for protamine 1 and 2 (PRM1 and PRM2) and transition protein 2 (TNP2) are closely linked in the mammalian genome". Cytogenet Cell Genet. 61 (2): 158–9. doi:10.1159/000133397. PMID 1395729.
6. ^ Baskaran R, Rao MR (Jan 1991). "Interaction of spermatid-specific protein TP2 with nucleic acids, in vitro. A comparative study with TP1". J Biol Chem. 265 (34): 21039–47. doi:10.1016/S0021-9258(17)45324-5. PMID 2250010.
7. ^ "Entrez Gene: TNP2 transition protein 2 (during histone to protamine replacement)".

• Schlüter G, Kremling H, Engel W (1992). "The gene for human transition protein 2: nucleotide sequence, assignment to the protamine gene cluster, and evidence for its low expression". Genomics. 14 (2): 377–83. doi:10.1016/S0888-7543(05)80229-0. PMID 1385303.
• Kundu TK, Rao MR (1995). "DNA condensation by the rat spermatidal protein TP2 shows GC-rich sequence preference and is zinc dependent". Biochemistry. 34 (15): 5143–50. doi:10.1021/bi00015a027. PMID 7711033.
• Nelson JE, Krawetz SA (1995). "Characterization of a human locus in transition". J. Biol. Chem. 269 (49): 31067–73. doi:10.1016/S0021-9258(18)47391-7. PMID 7983046.
• Nelson JE, Krawetz SA (1993). "Linkage of human spermatid-specific basic nuclear protein genes. Definition and evolution of the P1-->P2-->TP2 locus". J. Biol. Chem. 268 (4): 2932–6. doi:10.1016/S0021-9258(18)53863-1. PMID 8428967.
• Kundu TK, Rao MR (1997). "Zinc dependent recognition of a human CpG island sequence by the mammalian spermatidal protein TP2". Biochemistry. 35 (49): 15626–32. doi:10.1021/bi961271i. PMID 8961924.
• Steger K, Klonisch T, Gavenis K, et al. (1999). "Expression of mRNA and protein of nucleoproteins during human spermiogenesis". Mol. Hum. Reprod. 4 (10): 939–45. doi:10.1093/molehr/4.10.939. PMID 9809674.
• Wyckoff GJ, Wang W, Wu CI (2000). "Rapid evolution of male reproductive genes in the descent of man". Nature. 403 (6767): 304–9. Bibcode:2000Natur.403..304W. doi:10.1038/35002070. PMID 10659848. S2CID 3136139.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wykes SM, Krawetz SA (2003). "The structural organization of sperm chromatin". J. Biol. Chem. 278 (32): 29471–7. doi:10.1074/jbc.M304545200. PMID 12775710.
• Miyagawa Y, Nishimura H, Tsujimura A, et al. (2006). "Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations". J. Androl. 26 (6): 779–86. doi:10.2164/jandrol.05069. PMID 16291974.
• Jedrzejczak P, Kempisty B, Bryja A, et al. (2007). "Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men". Arch. Androl. 53 (4): 199–205. doi:10.1080/01485010701426430. PMID 17852044. S2CID 21999596.