TOMM70 (original) (raw)

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Protein-coding gene in the species Homo sapiens

TOMM70
Identifiers
Aliases	TOMM70, TOMM70A, Tom70, translocase of outer mitochondrial membrane 70
External IDs	OMIM: 606081; MGI: 106295; HomoloGene: 40112; GeneCards: TOMM70; OMA:TOMM70 - orthologs
Gene location (Human)Chr.Chromosome 3 (human)[1]Band3q12.2Start100,363,431 bp[1]End100,401,089 bp[1]
Gene location (Mouse)Chr.Chromosome 16 (mouse)[2]Band16 C1.1|16 34.22 cMStart56,942,066 bp[2]End56,977,068 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inendothelial cellglutesBrodmann area 23deltoid muscleparotid glandtriceps brachii muscleSkeletal muscle tissue of biceps brachiiSkeletal muscle tissue of rectus abdominisBrodmann area 46middle temporal gyrusTop expressed innucleus accumbensolfactory tuberclemedullary collecting ductglobus palliduscingulate gyrusAmygdaladorsomedial hypothalamic nucleusPaneth cellrenal corpuscleRegion I of hippocampus properMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function protein transmembrane transporter activity protein binding Cellular component mitochondrial outer membrane extracellular exosome integral component of membrane mitochondrial outer membrane translocase complex membrane mitochondrion Biological process macroautophagy protein targeting to mitochondrion protein transmembrane transport Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez986828185EnsemblENSG00000154174ENSMUSG00000022752UniProtO94826Q9CZW5RefSeq (mRNA)NM_014820NM_138599RefSeq (protein)NP_055635NP_613065Location (UCSC)Chr 3: 100.36 – 100.4 MbChr 16: 56.94 – 56.98 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitochondrial import receptor subunit TOM70, also known as translocase of outer mitochondrial membrane protein 70 is a protein that in humans is encoded by the TOMM70 gene.[5][6]

The translocase of the outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria. See TIM17A (MIM 605057).[supplied by OMIM][6]

• TOMM20
• TOMM22
• TOMM40

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154174 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022752 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Alvarez-Dolado M, Gonzalez-Moreno M, Valencia A, Zenke M, Bernal J, Munoz A (Dec 1999). "Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions". J Neurochem. 73 (6): 2240–9. doi:10.1046/j.1471-4159.1999.0732240.x. PMID 10582581. S2CID 23008591.
6. ^ a b "Entrez Gene: TOMM70 translocase of outer mitochondrial membrane 70 homolog Homo sapiens (human)".

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
• Edmonson AM, Mayfield DK, Vervoort V, et al. (2002). "Characterization of a human import component of the mitochondrial outer membrane, TOMM70A". Cell Commun. Adhes. 9 (1): 15–27. doi:10.1080/15419060212186. PMID 12200962.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Young JC, Hoogenraad NJ, Hartl FU (2003). "Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70". Cell. 112 (1): 41–50. doi:10.1016/S0092-8674(02)01250-3. PMID 12526792.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Humphries AD, Streimann IC, Stojanovski D, et al. (2005). "Dissection of the mitochondrial import and assembly pathway for human Tom40". J. Biol. Chem. 280 (12): 11535–43. doi:10.1074/jbc.M413816200. PMID 15644312.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Chou CH, Lee RS, Yang-Yen HF (2006). "An Internal EELD Domain Facilitates Mitochondrial Targeting of Mcl-1 via a Tom70-dependent Pathway". Mol. Biol. Cell. 17 (9): 3952–63. doi:10.1091/mbc.E06-04-0319. PMC 1593170. PMID 16822835.
• Fan AC, Bhangoo MK, Young JC (2006). "Hsp90 functions in the targeting and outer membrane translocation steps of Tom70-mediated mitochondrial import". J. Biol. Chem. 281 (44): 33313–24. doi:10.1074/jbc.M605250200. PMID 16968702.