TSPAN31 (original) (raw)

From Wikipedia, the free encyclopedia

Protein-coding gene in humans

TSPAN31
Identifiers
Aliases	TSPAN31, SAS, tetraspanin 31
External IDs	OMIM: 181035; MGI: 1914375; HomoloGene: 4359; GeneCards: TSPAN31; OMA:TSPAN31 - orthologs
Gene location (Human)Chr.Chromosome 12 (human)[1]Band12q14.1Start57,738,013 bp[1]End57,750,219 bp[1]
Gene location (Mouse)Chr.Chromosome 10 (mouse)[2]Band10|10 D3Start126,903,149 bp[2]End126,906,133 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed inpancreatic ductal cellislet of Langerhanspericardiumright lobe of thyroid glandright adrenal glandcorpus epididymisendothelial cellright adrenal cortexrenal medullagallbladderTop expressed inleft lobe of livermedullary collecting ductrenal corpusclecalvariacumulus cellmedial ganglionic eminencemolarvas deferensefferent ductuleaortic valveMore reference expression dataBioGPSMore reference expression data
OrthologsSpeciesHuman MouseEntrez630267125EnsemblENSG00000135452ENSMUSG00000006736UniProtQ12999Q9CQ88RefSeq (mRNA)NM_005981NM_001330168NM_001330169NM_025982RefSeq (protein)NP_001317097NP_001317098NP_005972NP_080258Location (UCSC)Chr 12: 57.74 – 57.75 MbChr 10: 126.9 – 126.91 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tetraspanin-31 is a protein that in humans is encoded by the TSPAN31 gene.[5]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma.[5]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135452 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006736 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ a b "Entrez Gene: TSPAN31 tetraspanin 31".

• Wright MD, Tomlinson MG (1995). "The ins and outs of the transmembrane 4 superfamily". Immunol. Today. 15 (12): 588–94. doi:10.1016/0167-5699(94)90222-4. PMID 7531445.
• Meltzer PS, Jankowski SA, Dal Cin P, et al. (1992). "Identification and cloning of a novel amplified DNA sequence in human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors". Cell Growth Differ. 2 (10): 495–501. PMID 1661131.
• Jankowski SA, De Jong P, Meltzer PS (1995). "Genomic structure of SAS, a member of the transmembrane 4 superfamily amplified in human sarcomas". Genomics. 25 (2): 501–6. doi:10.1016/0888-7543(95)80051-M. PMID 7789984.
• Jankowski SA, Mitchell DS, Smith SH, et al. (1994). "SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins". Oncogene. 9 (4): 1205–11. PMID 8134123.
• Elkahloun AG, Krizman DB, Wang Z, et al. (1997). "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers". Genomics. 42 (2): 295–301. doi:10.1006/geno.1997.4727. PMID 9192850.
• Wunder JS, Eppert K, Burrow SR, et al. (1999). "Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas". Oncogene. 18 (3): 783–8. doi:10.1038/sj.onc.1202346. PMID 9989829.
• Ragazzini P, Gamberi G, Benassi MS, et al. (1999). "Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma". Cancer Detect. Prev. 23 (2): 129–36. doi:10.1046/j.1525-1500.1999.09907.x. PMID 10101594.
• Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ragazzini P, Gamberi G, Pazzaglia L, et al. (2004). "Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma". Histol. Histopathol. 19 (2): 401–11. PMID 15024701.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.