Thiepine (original) (raw)

From Wikipedia, the free encyclopedia

Not to be confused with Thiepane.

Thiepine

Structural formula of thiepine Ball-and-stick model of the thiepine molecule
Names
Preferred IUPAC name Thiepine
Other namesThiatropilideneThiepin
Identifiers
CAS Number 291-72-5 checkY
3D model (JSmol) Interactive image
ChemSpider 13299847 checkY
PubChem CID 12444286
UNII 5A9XLZ8CPE checkY
CompTox Dashboard (EPA) DTXSID10498494 Edit this at Wikidata
InChI InChI=1S/C6H6S/c1-2-4-6-7-5-3-1/h1-6H checkYKey: BISQTCXKVNCDDA-UHFFFAOYSA-N checkY
SMILES S1C=CC=CC=C1
Properties
Chemical formula C6H6S
Molar mass 110.17 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ☒N verify (what is checkY☒N ?) Infobox references

Chemical compound

In organic chemistry, thiepine (or thiepin) is an unsaturated seven-membered heterocyclic compound, with six carbon atoms and one sulfur atom. The parent compound, C6H6S is unstable and is predicted to be antiaromatic. Bulky derivatives have been isolated and shown by X-ray crystallography to have nonplanar C6S ring.[1]

Computational studies suggest that thiepine would eliminate a sulfur atom to form benzene. The intermediate is this process is the bicycle thianorcaradiene. In the complex with (η4-C6H6S)Fe(CO)3, the ring is stable.[2]

Benzothiepines have one fused benzene group and dibenzothiepines such as dosulepin and zotepine have two fused benzene groups. Damotepine is another thiepin derivative.

The chemical structure of the dibenzothiepine zotepine.

  1. ^ Schwan, A. L., "Thiepins" Science of Synthesis, 2004, volume 17, 705. doi:10.1055/sos-SD-017-01065
  2. ^ Nishino, Keitaro; Takagi, Masanobu; Kawata, Teruhisa; Murata, Ichiro; Inanaga, Junji; Nakasuji, Kazuhiro (1991). "Thiepine-iron tricarbonyl: Stabilization of thermally labile parent thiepine by transition metal complexation". Journal of the American Chemical Society. 113 (13): 5059–5060. doi:10.1021/ja00013a051.