XPOT (original) (raw)

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

XPOT
Identifiers
Aliases	XPOT, XPO3, exportin for tRNA
External IDs	OMIM: 603180; MGI: 1920442; HomoloGene: 38291; GeneCards: XPOT; OMA:XPOT - orthologs
Gene location (Human)Chr.Chromosome 12 (human)[1]Band12q14.2Start64,404,392 bp[1]End64,451,125 bp[1]
Gene location (Mouse)Chr.Chromosome 10 (mouse)[2]Band10|10 D2Start121,423,285 bp[2]End121,462,237 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed instromal cell of endometriumendothelial cellBrodmann area 23islet of LangerhansAchilles tendonbone marrow cellsventricular zonebody of pancreasmiddle temporal gyrusganglionic eminenceTop expressed inureterlacrimal glandcalvariarenal corpusclefossacondyleparotid glandhair folliclesubstantia nigramedullary collecting ductMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function tRNA binding RNA binding Cellular component cytoplasm nuclear matrix nuclear pore nucleus nucleoplasm cytosol Biological process intracellular protein transport tRNA re-export from nucleus tRNA export from nucleus Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez1126073192EnsemblENSG00000184575ENSMUSG00000034667UniProtO43592Q9CRT8RefSeq (mRNA)NM_007235NM_001081056NM_001359618NM_001401044NM_001401045RefSeq (protein)NP_009166NP_001074525NP_001346547NP_001387973NP_001387974Location (UCSC)Chr 12: 64.4 – 64.45 MbChr 10: 121.42 – 121.46 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Exportin-T is a protein that in humans is encoded by the XPOT gene.[5][6][7]

This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN.[7]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184575 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034667 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Kutay U, Lipowsky G, Izaurralde E, Bischoff FR, Schwarzmaier P, Hartmann E, Gorlich D (Jul 1998). "Identification of a tRNA-specific nuclear export receptor". Mol Cell. 1 (3): 359–69. doi:10.1016/S1097-2765(00)80036-2. PMID 9660920.
6. ^ Arts GJ, Fornerod M, Mattaj IW (May 1998). "Identification of a nuclear export receptor for tRNA". Curr Biol. 8 (6): 305–14. doi:10.1016/S0960-9822(98)70130-7. PMID 9512417. S2CID 17803674.
7. ^ a b "Entrez Gene: XPOT exportin, tRNA (nuclear export receptor for tRNAs)".

• Arts GJ, Kuersten S, Romby P, et al. (1999). "The role of exportin-t in selective nuclear export of mature tRNAs". EMBO J. 17 (24): 7430–41. doi:10.1093/emboj/17.24.7430. PMC 1171087. PMID 9857198.
• Kruse C, Willkomm DK, Grünweller A, et al. (2000). "Export and transport of tRNA are coupled to a multi-protein complex". Biochem. J. 346 (1): 107–15. doi:10.1042/0264-6021:3460107. PMC 1220829. PMID 10657246.
• Kutay U, Hartmann E, Treichel N, et al. (2001). "Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily". J. Biol. Chem. 275 (51): 40163–8. doi:10.1074/jbc.M006242200. hdl:11858/00-001M-0000-0015-3D4E-B. PMID 11024021.
• Kuersten S, Arts GJ, Walther TC, et al. (2002). "Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains". Mol. Cell. Biol. 22 (16): 5708–20. doi:10.1128/MCB.22.16.5708-5720.2002. PMC 133969. PMID 12138183.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Suzuki T, Koyama Y, Hayakawa S, et al. (2006). "1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells". Biomed. Res. 27 (2): 89–92. doi:10.2220/biomedres.27.89. PMID 16707848.
• Li S, Sprinzl M (2007). "Interaction of immobilized human exportin-t with calf liver tRNA". RNA Biol. 3 (4): 145–9. doi:10.4161/rna.3.4.3679. PMID 17224653.