TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death (original) (raw)

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Títol: TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death
Autor: Frisén, JonásRío Fernández, José Antonio delSoriano García, EduardoBarbacid, MarianoSilos-Santiago, Inmaculada
Matèria: Hipocamp (Cervell)Neurones motoresTransducció de senyal cel·lularHippocampus (Brain)Motor neuronsCellular signal transduction
Data de publicació: 1997
Publicat per: Society for Neuroscience
Resum: Newborn mice carrying targeted mutations in genes encoding neurotrophins or their signaling Trk receptors display severe neuronal deficits in the peripheral nervous system but not in the CNS. In this study, we show that trkB (¿/¿) mice have a significant increase in apoptotic cell death in different regions of the brain during early postnatal life. The most affected region in the brain is the dentate gyrus of the hippocampus, although elevated levels of pyknotic nuclei were also detected in cortical layers II and III and V and VI, the striatum, and the thalamus. Furthermore, axotomized hippocampal and motor neurons of trkB (¿/¿) mice have significantly lower survival rates than those of wild-type littermates. These results suggest that neurotrophin signaling through TrkB receptors plays a role in the survival of CNS neurons during postnatal development. Moreover, they indicate that TrkB receptor signaling protects subpopulations of CNS neurons from injury- and axotomy-induced cell death.
Nota: Reproducció del document publicat a: http://www.jneurosci.org/content/17/10/3623
És part de: The Journal of Neuroscience, 1997, vol. 17, num. 10, p. 3623-3633
URI: http://hdl.handle.net/2445/25549
ISSN: 0270-6474
Apareix en les col·leccions: Articles publicats en revistes (Patologia i Terapèutica Experimental)

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