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I afraid that this change breaks an assumption in frame\_setlineno() about the state of the stack. This can corrupt the stack if you jump from the instruction which is a part of Python operation. For example FOR\_ITER expects an iterator on the stack. If you jump to the end of the loop from the middle of an assignment operator and skip say STORE\_FAST, you will left an arbitrary value on the stack. This can lead to unpredictable consequences.