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  Role of the GRK2/3 N-terminus in discriminating the endocytic effects of opioid agonist drugs
  Joy Li, Asuka Inoue, Aashish Manglik and Mark von Zastrow
  Molecular Pharmacology November 6, 2024, MOLPHARM-AR-2024-000951; DOI: https://doi.org/10.1124/molpharm.124.000951
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  Evaluation of allosteric NMDA receptor modulation by GluN2A-selective antagonists using pharmacological equilibrium modeling
  James S. Lotti, Jaron Jones, Jill C Farnsworth, Feng Yi, Fabao Zhao, Frank S. Menniti, Robert A Volkmann, Rasmus P. Clausen and Kasper B Hansen
  Molecular Pharmacology November 5, 2024, MOLPHARM-AR-2024-000975; DOI: https://doi.org/10.1124/molpharm.124.000975
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  Receptor determinants for ß-arrestin functional specificity at C-X-C chemokine receptor 5 (CXCR5)
  Joseph M. Crecelius, Aaren R. Manz, Sara Benzow and Adriano Marchese
  Molecular Pharmacology October 29, 2024, MOLPHARM-AR-2024-000942; DOI: https://doi.org/10.1124/molpharm.124.000942
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  The beta 2 adrenergic receptor cross-linked interactome identifies 14-3-3 proteins as regulating the availability of signaling-competent receptors
  Ian B. Chronis, Rachel Vistein, Avanti Gokhale, Victor Faundez and Manojkumar A. Puthenveedu
  Molecular Pharmacology October 24, 2024, MOLPHARM-AR-2024-000939; DOI: https://doi.org/10.1124/molpharm.124.000939
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  Agonists of the nuclear receptor PPARγ can produce biased signaling
  Mariah Rayl, Michelle D. Nemetchek, Andrew H Voss and Travis S. Hughes
  Molecular Pharmacology October 23, 2024, MOLPHARM-AR-2024-000992; DOI: https://doi.org/10.1124/molpharm.124.000992
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  Mechanisms of Action Underlying Conductance-modifying Positive Allosteric Modulators of the NMDA Receptor
  Elijah Z. Ullman, Riley E. Perszyk, Srinu Paladugu, Russell G Fritzemeier, Nicholas S. Akins, Leon Jacobs, Dennis C Liotta and Stephen F. Traynelis
  Molecular Pharmacology October 23, 2024, MOLPHARM-AR-2024-001019; DOI: https://doi.org/10.1124/molpharm.124.001019

Molecular Pharmacology publishes findings derived from the application of innovative structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology to basic pharmacological problems that provide mechanistic insights that are broadly important for the fields of pharmacology and toxicology. Relevant topics include:

• Molecular Signaling / Mechanism of Drug Action
• Chemical Biology / Drug Discovery
• Structure of Drug-Receptor Complex
• Systems Analysis of Drug Action
• Drug Transport / Metabolism