amoxapine (CHEBI:2675) (original) (raw)

Monoisotopic Mass 313.09819
InChIKey QWGDMFLQWFTERH-UHFFFAOYSA-N
SMILES Clc1ccc2Oc3ccccc3N=C(N3CCNCC3)c2c1
Roles Classification
Biological Role(s): adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
Application(s): geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.

View more via ChEBI Ontology

IUPAC Name
2-chloro-11-(piperazin-1-yl)dibenzo[b,_f_][1,4]oxazepine
Synonyms Sources
2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine NIST Chemistry WebBook
Desmethylloxapin ChemIDplus
Manual Xrefs Databases
191 DrugCentral
Amoxapine Wikipedia
D00228 KEGG DRUG
DB00543 DrugBank
FR1508536 Patent
LSM-2021 LINCS
US3663696 Patent
View more database links
Registry Numbers Types Sources
14028-44-5 CAS Registry Number DrugBank
14028-44-5 CAS Registry Number KEGG DRUG
14028-44-5 CAS Registry Number ChemIDplus
14028-44-5 CAS Registry Number NIST Chemistry WebBook
832057 Beilstein Registry Number Beilstein
Citation Waiting for Citations Type Source
24134630 PubMed citation Europe PMC
Last Modified
17 September 2021