wxPython's setup.py needs to give the -I flags to the rc.exe command so the #include in the .rc file can find the specified file. This little one line change to msvccompiler.py adds all the -I and -D flags used for the C compiler to the RC compiler as well, and solves wxPython's problem. BTW, this is the last distutils thing that I have to workaround in wxPython's setup.py. With the distutils in 2.3 I will be able to remove all my other hacks. If this patch makes it in the final then they will all be gone.