Current Opinion in Obstetrics and Gynecology (original) (raw)

Current Issue Highlights

EDITORIAL INTRODUCTIONS

FERTILITY, IVF AND REPRODUCTIVE GENETICS

Role of serum progesterone levels in frozen embryo transfer: an update

Labarta, Elena; Giudice, Linda C.; Humaidan, Peter

Labarta, Elena; Giudice, Linda C.; Humaidan, Peter Less

Current Opinion in Obstetrics and Gynecology. 38(3):139-146, June 2026.

Plain Language Summary This review examines how serum progesterone levels affect success rates in ART, focusing on FET cycles. It summarizes recent studies showing that low mid-luteal serum progesterone is consistently linked to reduced implantation and live birth rates, especially in hormone replacement therapy endometrial preparation cycles, which are highly sensitive to inadequate progesterone. The authors highlight a shift from uniform, empirical luteal support to individualized strategies, such as adjusting progesterone dose or route based on measured serum levels. They call for future research to establish clear serum cutoff values, distinguish the roles of systemic versus endometrial progesterone, and optimize tailored luteal phase support in ART.

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Is there a role for radiofrequency and assisted reproductive technology?

Cerrillo, María; Caballero, Sergio

Cerrillo, María; Caballero, Sergio Less

Current Opinion in Obstetrics and Gynecology. 38(3):147-153, June 2026.

Plain Language Summary This review examined how effective and safe transvaginal radiofrequency ablation (TRFA) is for treating uterine fibroids and adenomyosis in infertile women, and whether it can serve as a fertility-preserving alternative to myomectomy. TRFA works by inducing coagulative necrosis in fibroid tissue and achieves about a 60–70% reduction in fibroid volume within 1 year while maintaining uterine anatomy. Reported pregnancy rates, via both spontaneous conception and assisted reproductive techniques, are similar to those of the general population, with no uterine ruptures or major obstetric complications linked to TRFA. Larger initial fibroid volume may delay conception, but overall TRFA offers a safe, minimally invasive option to optimize the uterus before pregnancy, especially in women with intramural fibroids.

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