CDKN1B gene cDNA ORF clone, Homo sapiens(human) (original) (raw)

• Summary

  Gene Symbol	CDKN1B
  Entrez Gene ID	1027
  Full Name	cyclin dependent kinase inhibitor 1B
  Synonyms	CDKN4,KIP1,MEN1B,MEN4,P27KIP1
  General protein information	Preferred Namescyclin dependent kinase inhibitor 1B Namescyclin-dependent kinase inhibitor 1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)
  Gene Type	protein-coding
  Organism	Homo sapiens(human)
  Genome	Chromosome: 12 Map Location: 12p13.1
  Summary	This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014].
  Disorder MIM:	600778
  Disorder Html:	Multiple endocrine neoplasia, type IV, 610755 (3)

• mRNA and Protein(s)

  mRNA	Protein	Name
  NM_004064.4	NP_004055.1	cyclin-dependent kinase inhibitor 1B

• Pathways from BioSystems
  
• Homologies

  Pan troglodytes (chimpanzee)	CDKN1B	XP_522347.3
  Canis lupus familiaris (dog)	CDKN1B	NP_001002957.1
  Bos taurus (cattle)	CDKN1B	NP_001093816.1
  CDKN1B	XP_001085433.1
  Danio rerio (zebrafish)	cdkn1bb	NP_997957.1
  Danio rerio (zebrafish)	LOC100534692	XP_003201420.1
  Rattus norvegicus (Norway rat)	Cdkn1b	NP_113950.2
  Homo sapiens (human)	CDKN1B	NP_004055.1
  Mus musculus (house mouse)	Cdkn1b	NP_034005.2
  Gallus gallus (chicken)	CDKN1B	NP_989587.1

• Gene Ontology
  
• Bibliography

Related articles in PubMed

A novel mutation in the upstream open reading frame of the CDKN1B gene causes a MEN4 phenotype.
Occhi G, Regazzo D, Trivellin G, Boaretto F, Ciato D, Bobisse S, Ferasin S, Cetani F, Pardi E, Korbonits M, Pellegata NS, Sidarovich V, Quattrone A, Opocher G, Mantero F, Scaroni C
PLoS genetics9(3)e1003350(2013 Mar)
Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans.
Pellegata NS, Quintanilla-Martinez L, Siggelkow H, Samson E, Bink K, H?fler H, Fend F, Graw J, Atkinson MJ
Proceedings of the National Academy of Sciences of the United States of America103(42)15558-63(2006 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CDKN1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDKN1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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• Reference Sequences (Refseq)

161121181241301361421481541	ATGTCAAACG TGCGAGTGTC TAACGGGAGC CCTAGCCTGG AGCGGATGGA CGCCAGGCAG GCGGAGCACC CCAAGCCCTC GGCCTGCAGG AACCTCTTCG GCCCGGTGGA CCACGAAGAG TTAACCCGGG ACTTGGAGAA GCACTGCAGA GACATGGAAG AGGCGAGCCA GCGCAAGTGG AATTTCGATT TTCAGAATCA CAAACCCCTA GAGGGCAAGT ACGAGTGGCA AGAGGTGGAG AAGGGCAGCT TGCCCGAGTT CTACTACAGA CCCCCGCGGC CCCCCAAAGG TGCCTGCAAG GTGCCGGCGC AGGAGAGCCA GGATGTCAGC GGGAGCCGCC CGGCGGCGCC TTTAATTGGG GCTCCGGCTA ACTCTGAGGA CACGCATTTG GTGGACCCAA AGACTGATCC GTCGGACAGC CAGACGGGGT TAGCGGAGCA ATGCGCAGGA ATAAGGAAGC GACCTGCAAC CGACGATTCT TCTACTCAAA ACAAAAGAGC CAACAGAACA GAAGAAAATG TTTCAGACGG TTCCCCAAAT GCCGGTTCTG TGGAGCAGAC GCCCAAGAAG CCTGGCCTCA GAAGACGTCA AACGTAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq	NP_004055.1
---------------	------------
CDS	571..1167
Translation
Target ORF information: RefSeq Version NM_004064.4 Organism Homo sapiens(human) Definition Homo sapiens cyclin dependent kinase inhibitor 1B (CDKN1B), mRNA. Target ORF information: Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK	NM_004064.4
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------	-----------------------------------------------------------------

ORF Insert Sequence:

• PubMed

  A novel mutation in the upstream open reading frame of the CDKN1B gene causes a MEN4 phenotype. PLoS genetics9(3)e1003350(2013 Mar) Occhi G,Regazzo D,Trivellin G,Boaretto F,Ciato D,Bobisse S,Ferasin S,Cetani F,Pardi E,Korbonits M,Pellegata NS,Sidarovich V,Quattrone A,Opocher G,Mantero F,Scaroni C

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