Pklr gene cDNA ORF clone, Rattus norvegicus(Norway rat) (original) (raw)

• Summary

  Gene Symbol	Pklr
  Entrez Gene ID	24651
  Full Name	pyruvate kinase L/R
  Synonyms	PK1,PKL,Pklg
  General protein information	Preferred Namespyruvate kinase L/R Namespyruvate kinase PKLRL-PKpyruvate kinase isozymes L/Rpyruvate kinase isozymes R/Lpyruvate kinase, liver and RBCpyruvate kinase, liver and red blood cell
  Gene Type	protein-coding
  Organism	Rattus norvegicus(Norway rat)
  Genome	Chromosome: 2 Map Location: 2q34
  Summary	L-isozyme of pyruvate kinase; catalyzes the conversion of ATP and pyruvate to ADP and phosphoenolpyruvate in glycolysis [RGD, Feb 2006].

• mRNA and Protein(s)

  mRNA	Protein	Name
  NM_012624.3	NP_036756.3	pyruvate kinase PKLR
  XM_006232593.3	XP_006232655.1	pyruvate kinase PKLR isoform X1
  XM_017590631.1	XP_017446120.1	pyruvate kinase PKLR isoform X2

• Pathways from BioSystems
  
• Homologies

  PKLR	XP_001112902.2
  Danio rerio (zebrafish)	pklr	NP_958446.1
  Arabidopsis thaliana (thale cress)	AT3G55650	NP_191124.1
  Homo sapiens (human)	PKLR	NP_000289.1
  Canis lupus familiaris (dog)	PKLR	NP_001243191.1
  Bos taurus (cattle)	PKLR	NP_001069644.1
  Mus musculus (house mouse)	Pklr	NP_038659.2
  Saccharomyces cerevisiae (baker's yeast)	PYK2	NP_014992.3
  Arabidopsis thaliana (thale cress)	AT3G55810	NP_191140.1
  Rattus norvegicus (Norway rat)	Pklr	NP_036756.3
  Arabidopsis thaliana (thale cress)	AT3G25960	NP_189225.1
  Pan troglodytes (chimpanzee)	PKLR	XP_524896.4
  Arabidopsis thaliana (thale cress)	AT3G04050	NP_187055.1

• Gene Ontology
  
• Bibliography

Related articles in PubMed

Red blood cell PK deficiency: An update of PK-LR gene mutation database.
Canu G, De Bonis M, Minucci A, Capoluongo E
Blood cells, molecules & diseases57100-9(2016 Mar)
Probing L-pyruvate kinase regulatory phosphorylation site by mutagenesis.
Faustova I, Loog M, J?rv J
The protein journal31(7)592-7(2012 Oct)
Hypermethylation of hepatic glucokinase and L-type pyruvate kinase promoters in high-fat diet-induced obese rats.
Jiang M, Zhang Y, Liu M, Lan MS, Fei J, Fan W, Gao X, Lu D
Endocrinology152(4)1284-9(2011 Apr)
Malaria: looking for selection signatures in the human PKLR gene region.
Machado P, Pereira R, Rocha AM, Manco L, Fernandes N, Miranda J, Ribeiro L, do Ros?rio VE, Amorim A, Gusm?o L, Arez AP
British journal of haematology149(5)775-84(2010 Jun)
Rescue of pyruvate kinase deficiency in mice by gene therapy using the human isoenzyme.
Meza NW, Alonso-Ferrero ME, Navarro S, Quintana-Bustamante O, Valeri A, Garcia-Gomez M, Bueren JA, Bautista JM, Segovia JC
Molecular therapy : the journal of the American Society of Gene Therapy17(12)2000-9(2009 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Pklr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pklr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

• Reference Sequences (Refseq)

16112118124130136142148154160166172178184190196110211081114112011261132113811441150115611621	ATGGAAGGGC CAGCGGGATA CCTTCGACGT GCGAGTGTGG CTCAACTGAC CCAGGAGCTG GGCACTGCCT TCTTCCAGCA GCAGCAACTG CCCGCAGCTA TGGCGGACAC CTTCCTGGAA CACCTCTGCC TTCTGGATAT CGACTCACAG CCTGTGGCTG CTCGTAGCAC CAGCATCATT GCCACCATTG GGCCAGCATC CCGCTCTGTG GACCGCCTCA AGGAGATGAT CAAAGCAGGG ATGAACATTG CACGACTCAA CTTCTCCCAT GGCTCCCATG AGTACCATGC AGAATCCATC GCCAACATCC GGGAGGCAAC TGAGAGTTTT GCAACCTCCC CACTCAGCTA CAGACCTGTG GCCATCGCCC TGGACACCAA GGGACCTGAG ATACGAACCG GAGTCTTGCA GGGGGGTCCG GAGTCGGAGG TGGAAATTGT GAAGGGCTCA CAGGTGCTGG TGACGGTGGA CCCGAAGTTC CAGACAAGGG GCGATGCAAA GACAGTGTGG GTGGACTACC ACAATATCAC CCGGGTCGTT GCAGTGGGGG GCCGCATCTA CATTGACGAC GGGCTCATCT CCTTAGTGGT ACAGAAAATC GGCCCAGAGG GACTGGTGAC AGAAGTGGAG CACGGTGGTA TCTTGGGCAG CAGGAAGGGT GTGAACTTGC CAAACACTGA GGTGGACCTG CCCGGGCTGT CTGAGCAAGA CCTTTTGGAT CTGCGCTTCG GGGTGCAGCA TAATGTGGAC ATCATCTTTG CCTCCTTTGT GCGGAAAGCC AGTGACGTGT TAGCAGTCCG GGATGCCCTG GGGCCAGAAG GACAGAACAT CAAAATTATC AGCAAAATCG AGAACCATGA AGGCGTGAAG AAGTTTGATG AAATTCTAGA AGTGAGCGAT GGCATCATGG TGGCACGGGG TGACCTGGGC ATTGAGATCC CTGCGGAGAA GGTTTTCTTG GCTCAGAAGA TGATGATTGG ACGCTGCAAC CTGGCCGGCA AGCCTGTCGT TTGTGCCACA CAGATGCTGG AGAGCATGAT CACTAAGGCT CGACCAACTC GGGCGGAGAC AAGCGATGTG GCCAATGCCG TGCTGGATGG GGCTGACTGT ATCATGCTGT CCGGAGAGAC CGCCAAGGGC AGTTTTCCTG TGGAAGCTGT AATGATGCAA CATGCGATTG CGCGGGAGGC AGAGGCCGCT GTGTACCACC GCCAGTTGTT TGAGGAGCTA CGCCGGGCAG CGCCGCTGAG CCGTGACCCA ACTGAGGTCA CTGCGATTGG AGCCGTGGAG GCTTCCTTCA AGTGCTGTGC AGCAGCCATC ATCGTGCTGA CGAAGACTGG CCGTTCAGCC CAGCTTCTAT CTCAATACCG ACCTCGGGCG GCTGTCATTG CTGTGACTCG ATCTGCCCAG GCTGCCCGAC AGGTCCACCT GTCCCGAGGA GTCTTCCCCT TGCTCTACCG TGAGCCTCCA GAGGCCATCT GGGCAGATGA TGTGGATCGA AGGGTCCAAT TTGGCATTGA AAGTGGAAAG CTCCGTGGTT TCCTCCGTGT GGGTGATCTG GTGATTGTGG TGACAGGTTG GCGGCCTGGC TCTGGCTATA CCAACATCAT GCGGGTGCTG AGCGTATCCT GA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq	NP_036756.3
---------------	------------
CDS	16..1647
Translation
Target ORF information: RefSeq Version NM_012624.3 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus pyruvate kinase L/R (Pklr), mRNA. Target ORF information: Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK	NM_012624.3
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------	-----------------------------------------------------------------

ORF Insert Sequence:

161121181241301361421481541601661721781841901961102110811141120112611321138114411501156116211681	ATGTCTGTCC AGGAGAACAC TCTACCCCAG CAGCTCTGGC CGTGGATCTT TAGGTCCCAA AAAGACTTGG CAAAGTCTGC CTTAAGTGGG GCTCCCGGAG GGCCAGCGGG ATACCTTCGA CGTGCGAGTG TGGCTCAACT GACCCAGGAG CTGGGCACTG CCTTCTTCCA GCAGCAGCAA CTGCCCGCAG CTATGGCGGA CACCTTCCTG GAACACCTCT GCCTTCTGGA TATCGACTCA CAGCCTGTGG CTGCTCGTAG CACCAGCATC ATTGCCACCA TTGGGCCAGC ATCCCGCTCT GTGGACCGCC TCAAGGAGAT GATCAAAGCA GGGATGAACA TTGCACGACT CAACTTCTCC CATGGCTCCC ATGAGTACCA TGCAGAATCC ATCGCCAACA TCCGGGAGGC AACTGAGAGT TTTGCAACCT CCCCACTCAG CTACAGACCT GTGGCCATCG CCCTGGACAC CAAGGGACCT GAGATACGAA CCGGAGTCTT GCAGGGGGGT CCGGAGTCGG AGGTGGAAAT TGTGAAGGGC TCACAGGTGC TGGTGACGGT GGACCCGAAG TTCCAGACAA GGGGCGATGC AAAGACAGTG TGGGTGGACT ACCACAATAT CACCCGGGTC GTTGCAGTGG GGGGCCGCAT CTACATTGAC GACGGGCTCA TCTCCTTAGT GGTACAGAAA ATCGGCCCAG AGGGACTGGT GACAGAAGTG GAGCACGGTG GTATCTTGGG CAGCAGGAAG GGTGTGAACT TGCCAAACAC TGAGGTGGAC CTGCCCGGGC TGTCTGAGCA AGACCTTTTG GATCTGCGCT TCGGGGTGCA GCATAATGTG GACATCATCT TTGCCTCCTT TGTGCGGAAA GCCAGTGACG TGTTAGCAGT CCGGGATGCC CTGGGGCCAG AAGGACAGAA CATCAAAATT ATCAGCAAAA TCGAGAACCA TGAAGGCGTG AAGAAGTTTG ATGAAATTCT AGAAGTGAGC GATGGCATCA TGGTGGCACG GGGTGACCTG GGCATTGAGA TCCCTGCGGA GAAGGTTTTC TTGGCTCAGA AGATGATGAT TGGACGCTGC AACCTGGCCG GCAAGCCTGT CGTTTGTGCC ACACAGATGC TGGAGAGCAT GATCACTAAG GCTCGACCAA CTCGGGCGGA GACAAGCGAT GTGGCCAATG CCGTGCTGGA TGGGGCTGAC TGTATCATGC TGTCCGGAGA GACCGCCAAG GGCAGTTTTC CTGTGGAAGC TGTAATGATG CAACATGCGA TTGCGCGGGA GGCAGAGGCC GCTGTGTACC ACCGCCAGTT GTTTGAGGAG CTACGCCGGG CAGCGCCGCT GAGCCGTGAC CCAACTGAGG TCACTGCGAT TGGAGCCGTG GAGGCTTCCT TCAAGTGCTG TGCAGCAGCC ATCATCGTGC TGACGAAGAC TGGCCGTTCA GCCCAGCTTC TATCTCAATA CCGACCTCGG GCGGCTGTCA TTGCTGTGAC TCGATCTGCC CAGGCTGCCC GACAGGTCCA CCTGTCCCGA GGAGTCTTCC CCTTGCTCTA CCGTGAGCCT CCAGAGGCCA TCTGGGCAGA TGATGTGGAT CGAAGGGTCC AATTTGGCAT TGAAAGTGGA AAGCTCCGTG GTTTCCTCCG TGTGGGTGAT CTGGTGATTG TGGTGACAGG TTGGCGGCCT GGCTCTGGCT ATACCAACAT CATGCGGGTG CTGAGCGTAT CCTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq	XP_006232655.1
---------------	---------------
CDS	53..1777
Translation
Target ORF information: RefSeq Version XM_006232593.3 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus pyruvate kinase, liver and RBC (Pklr), transcript variant X1, mRNA. Target ORF information: Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK	XM_006232593.3
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------	--------------------------------------------------------------------

ORF Insert Sequence:

161121181241301361421481541601661721781841901961102110811141120112611321138114411501	ATGGCGGACA CCTTCCTGGA ACACCTCTGC CTTCTGGATA TCGACTCACA GCCTGTGGCT GCTCGTAGCA CCAGCATCAT TGCCACCATT GGGCCAGCAT CCCGCTCTGT GGACCGCCTC AAGGAGATGA TCAAAGCAGG GATGAACATT GCACGACTCA ACTTCTCCCA TGGCTCCCAT GAGTACCATG CAGAATCCAT CGCCAACATC CGGGAGGCAA CTGAGAGTTT TGCAACCTCC CCACTCAGCT ACAGACCTGT GGCCATCGCC CTGGACACCA AGGGACCTGA GATACGAACC GGAGTCTTGC AGGGGGGTCC GGAGTCGGAG GTGGAAATTG TGAAGGGCTC ACAGGTGCTG GTGACGGTGG ACCCGAAGTT CCAGACAAGG GGCGATGCAA AGACAGTGTG GGTGGACTAC CACAATATCA CCCGGGTCGT TGCAGTGGGG GGCCGCATCT ACATTGACGA CGGGCTCATC TCCTTAGTGG TACAGAAAAT CGGCCCAGAG GGACTGGTGA CAGAAGTGGA GCACGGTGGT ATCTTGGGCA GCAGGAAGGG TGTGAACTTG CCAAACACTG AGGTGGACCT GCCCGGGCTG TCTGAGCAAG ACCTTTTGGA TCTGCGCTTC GGGGTGCAGC ATAATGTGGA CATCATCTTT GCCTCCTTTG TGCGGAAAGC CAGTGACGTG TTAGCAGTCC GGGATGCCCT GGGGCCAGAA GGACAGAACA TCAAAATTAT CAGCAAAATC GAGAACCATG AAGGCGTGAA GAAGTTTGAT GAAATTCTAG AAGTGAGCGA TGGCATCATG GTGGCACGGG GTGACCTGGG CATTGAGATC CCTGCGGAGA AGGTTTTCTT GGCTCAGAAG ATGATGATTG GACGCTGCAA CCTGGCCGGC AAGCCTGTCG TTTGTGCCAC ACAGATGCTG GAGAGCATGA TCACTAAGGC TCGACCAACT CGGGCGGAGA CAAGCGATGT GGCCAATGCC GTGCTGGATG GGGCTGACTG TATCATGCTG TCCGGAGAGA CCGCCAAGGG CAGTTTTCCT GTGGAAGCTG TAATGATGCA ACATGCGATT GCGCGGGAGG CAGAGGCCGC TGTGTACCAC CGCCAGTTGT TTGAGGAGCT ACGCCGGGCA GCGCCGCTGA GCCGTGACCC AACTGAGGTC ACTGCGATTG GAGCCGTGGA GGCTTCCTTC AAGTGCTGTG CAGCAGCCAT CATCGTGCTG ACGAAGACTG GCCGTTCAGC CCAGCTTCTA TCTCAATACC GACCTCGGGC GGCTGTCATT GCTGTGACTC GATCTGCCCA GGCTGCCCGA CAGGTCCACC TGTCCCGAGG AGTCTTCCCC TTGCTCTACC GTGAGCCTCC AGAGGCCATC TGGGCAGATG ATGTGGATCG AAGGGTCCAA TTTGGCATTG AAAGTGGAAA GCTCCGTGGT TTCCTCCGTG TGGGTGATCT GGTGATTGTG GTGACAGGTT GGCGGCCTGG CTCTGGCTAT ACCAACATCA TGCGGGTGCT GAGCGTATCC TGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq	XP_017446120.1
---------------	---------------
CDS	259..1791
Translation
Target ORF information: RefSeq Version XM_017590631.1 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus pyruvate kinase, liver and RBC (Pklr), transcript variant X2, mRNA. Target ORF information: Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK	XM_017590631.1
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------	--------------------------------------------------------------------

ORF Insert Sequence:

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