Traf1 MGI Mouse Gene Detail - MGI:101836 (original) (raw)

Summary

Symbol
Traf1
Name
TNF receptor-associated factor 1
Synonyms
4732496E14Rik
Feature Type
protein coding gene
IDs
MGI:101836
NCBI Gene:22029
Alliance
Transcription Start Sites
17 TSS

Location &
Maps

Sequence Map
Chr2:34831762-34851784 bp, - strand
From NCBI annotation of GRCm39
Genome Browsers
Genetic Map
Chromosome 2, 23.13 cM
Mapping Data
2 experiments

Strain
Comparison

SNPs within 2kb
575 from dbSNP Build 142
Strain Annotations
18

Homology

Human Ortholog
TRAF1, TNF receptor associated factor 1
Vertebrate Orthologs
3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog
TRAF1, TNF receptor associated factor 1
Synonyms
EBI6, MGC:10353
Links
Chr Location
9q33.2; chr9:120902393-120929173 (-) GRCh38

MGI Vertebrate Homology
HCOP
vertebrate homology predictions:TRAF1
Protein SuperFamily
Gene Tree

Mutations,
Alleles, and
Phenotypes

less

Phenotype Summary
5 phenotypes from 1 allele in 1 genetic background
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles
Endonuclease-mediated
Gene trapped
Targeted
Incidental Mutations
Find Mice (IMSR)
Comparison Matrix

Homozygous null mice exhibit abnormal T cell functionality.

Gene Ontology
(GO)
Classifications

less

All GO Annotations
GO References

Molecular Function carbohydrate derivative binding cytoskeletal protein binding DNA binding enzyme regulator hydrolase ligase lipid binding oxidoreductase RNA binding signaling receptor activity signaling receptor binding transcription transferase transporter Biological Process carbohydrate derivative metabolism cell differentiation cell population proliferation cellular component organization DNA-templated transcription establishment of localization homeostatic process immune system process lipid metabolic process programmed cell death protein metabolic process response to stimulus signaling system development Cellular Component cell projection cytoplasmic vesicle cytoskeleton cytosol endoplasmic reticulum endosome extracellular region Golgi apparatus mitochondrion membraneless organelle nucleus organelle envelope organelle lumen plasma membrane protein-containing complex synapse vacuole Click cells to view annotations.

Expression

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results
Tissues
cDNA Data
Literature Summary
Other Mouse Links

Sequences &
Gene Models

less

All Sequences
RefSeq
UniProt
CCDS
Ensembl
NCBI Gene

Protein
Information

less

UniProt
5 Sequences
Protein Ontology
InterPro Domains
IPR037306 TNF receptor-associated factor 1, MATH domain
IPR032070 TNF receptor-associated factor, BIRC3 binding domain
IPR012227 TNF receptor-associated factor TRAF, metazoa
IPR049342 TRAF1-6/MEP1A/B-like, MATH domain

Molecular
Reagents

less

All nucleic 26
Genomic 1
Primer pair 1
Other 2
Microarray probesets 4

Other
Accession IDs

less

MGD-MRK-18657, MGI:2443877

References

Summaries
Developmental Gene Expression 8
Gene Ontology 9
Phenotypes 30
Earliest
J:19898 Rothe M, et al., A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell. 1994 Aug 26;78(4):681-92
Latest
J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;