Prss2 MGI Mouse Gene Detail - MGI:102759 (original) (raw)

Summary

Symbol
Prss2
Name
serine protease 2
Synonyms
Ta, Tesp4, Try2, TRY8, TRYP
Feature Type
protein coding gene
IDs
MGI:102759
NCBI Gene:22072
Alliance
Transcription Start Sites
11 TSS

Location &
Maps

Sequence Map
Chr6:41498721-41502013 bp, + strand
From Ensembl annotation of GRCm39
Genome Browsers
Genetic Map
Chromosome 6, 19.67 cM
Mapping Data
1 experiment

Strain
Comparison

SNPs within 2kb
218 from dbSNP Build 142
Strain Annotations
18

Homology

Human Ortholog
PRSS2, serine protease 2
Vertebrate Orthologs
3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog
PRSS2, serine protease 2
Synonyms
TRY2, TRY8, TRYP2
Links
Chr Location
7q34; chr7:142760398-142774564 (+) GRCh38

MGI Vertebrate Homology
HCOP
vertebrate homology predictions:PRSS2
Gene Tree

Human Diseases

Diseases
1 with human PRSS1 associations

Mutations,
Alleles, and
Phenotypes

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Phenotype Summary
8 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles
Endonuclease-mediated
Targeted
Find Mice (IMSR)
Comparison Matrix

Gene Ontology
(GO)
Classifications

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All GO Annotations
GO References

Molecular Function carbohydrate derivative binding cytoskeletal protein binding DNA binding enzyme regulator hydrolase ligase lipid binding oxidoreductase RNA binding signaling receptor activity signaling receptor binding transcription transferase transporter Biological Process carbohydrate derivative metabolism cell differentiation cell population proliferation cellular component organization DNA-templated transcription establishment of localization homeostatic process immune system process lipid metabolic process programmed cell death protein metabolic process response to stimulus signaling system development Cellular Component cell projection cytoplasmic vesicle cytoskeleton cytosol endoplasmic reticulum endosome extracellular region Golgi apparatus mitochondrion membraneless organelle nucleus organelle envelope organelle lumen plasma membrane protein-containing complex synapse vacuole Click cells to view annotations.

Expression

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results
Tissues
cDNA Data
Literature Summary
Other Mouse Links
Other Vertebrate Links

Sequences &
Gene Models

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All Sequences
RefSeq
UniProt
CCDS
Ensembl
NCBI Gene

Protein
Information

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UniProt
2 Sequences
Protein Ontology
EC
InterPro Domains
IPR001314 Peptidase S1A, chymotrypsin family
IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
IPR050127 Serine Proteases (Peptidase S1 Family)
IPR001254 Serine proteases, trypsin domain
IPR018114 Serine proteases, trypsin family, histidine active site
IPR033116 Serine proteases, trypsin family, serine active site
GlyGen
P07146 1 site, 1 O-linked glycan (1 site)

Molecular
Reagents

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All nucleic 573
Genomic 1
Microarray probesets 4

References

Summaries
Developmental Gene Expression 4
Gene Ontology 8
Phenotypes 9
Earliest
J:8507 Stevenson BJ, et al., Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes. Nucleic Acids Res. 1986 Nov 11;14(21):8307-30
Latest
J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136