Rock1 MGI Mouse Gene Detail - MGI:107927 (original) (raw)

Summary

Symbol
Rock1
Name
Rho-associated coiled-coil containing protein kinase 1
Synonyms
1110055K06Rik, Rock-I
Feature Type
protein coding gene
IDs
MGI:107927
NCBI Gene:19877
Alliance
Transcription Start Sites
18 TSS

Location &
Maps

Sequence Map
Chr18:10064401-10182045 bp, - strand
From Ensembl annotation of GRCm39
Genome Browsers
Genetic Map
Chromosome 18, 4.91 cM, cytoband A2
Mapping Data
3 experiments

Strain
Comparison

SNPs within 2kb
2145 from dbSNP Build 142
Strain Annotations
18

Homology

Human Ortholog
ROCK1, Rho associated coiled-coil containing protein kinase 1
Vertebrate Orthologs
3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog
ROCK1, Rho associated coiled-coil containing protein kinase 1
Synonyms
P160ROCK, ROCK-I
Links
Chr Location
18q11.1; chr18:20944612-21111813 (-) GRCh38

MGI Vertebrate Homology
HCOP
vertebrate homology predictions:ROCK1
Gene Tree

Mutations,
Alleles, and
Phenotypes

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Phenotype Summary
38 phenotypes from 7 alleles in 7 genetic backgrounds
12 phenotypes from multigenic genotypes
6 images
64 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles
Endonuclease-mediated
Gene trapped
Targeted
Incidental Mutations
Find Mice (IMSR)
Comparison Matrix

Homozygous null mice have open eyes at birth, omphalocele and most die soon after birth as a result of cannibalization by the mom. Survivors develop inflammation of the eyelid. Another homozygous mutant shows partial lethality around implantation and reduced cardiac fibrosis after pressure overload.

Gene Ontology
(GO)
Classifications

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All GO Annotations
GO References

Molecular Function carbohydrate derivative binding cytoskeletal protein binding DNA binding enzyme regulator hydrolase ligase lipid binding oxidoreductase RNA binding signaling receptor activity signaling receptor binding transcription transferase transporter Biological Process carbohydrate derivative metabolism cell differentiation cell population proliferation cellular component organization DNA-templated transcription establishment of localization homeostatic process immune system process lipid metabolic process programmed cell death protein metabolic process response to stimulus signaling system development Cellular Component cell projection cytoplasmic vesicle cytoskeleton cytosol endoplasmic reticulum endosome extracellular region Golgi apparatus mitochondrion non-membrane-bounded organelle nucleus organelle envelope organelle lumen plasma membrane protein-containing complex synapse vacuole Click cells to view annotations.

Expression

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results
Tissues
cDNA Data
Literature Summary
Other Mouse Links
Other Vertebrate Links

Sequences &
Gene Models

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All Sequences
RefSeq
UniProt
CCDS
Ensembl
NCBI Gene

Protein
Information

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UniProt
5 Sequences
Protein Ontology
EC
InterPro Domains
IPR017441 Protein kinase, ATP binding site
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR011009 Protein kinase-like domain superfamily
IPR020684 Rho-associated protein kinase 1/2
IPR037310 Rho-associated protein kinase 1, HR1
IPR050839 Rho-associated Serine/Threonine Kinase
IPR008271 Serine/threonine-protein kinase, active site
GlyGen
P70335 1 site, 1 O-linked glycan (1 site)

Molecular
Reagents

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All nucleic 29
Primer pair 5
Microarray probesets 7

Other
Accession IDs

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MGD-MRK-36507, MGI:1916035

References

Summaries
Developmental Gene Expression 30
Gene Ontology 22
Phenotypes 64
Earliest
J:35061 Nakagawa O, et al., ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 1996 Aug 26;392(2):189-93
Latest
J:350506 Akamine T, et al., Conditional deficiency of Rho-associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice. FEBS Open Bio. 2024 Jun;14(6):906-921