Fam3b MGI Mouse Gene Detail - MGI:1270150 (original) (raw)

Summary

Symbol
Fam3b
Name
FAM3 metabolism regulating signaling molecule B
Synonyms
9030624C24Rik, D16Jhu19e, ORF9, Pander
Feature Type
protein coding gene
IDs
MGI:1270150
NCBI Gene:52793
Alliance
Transcription Start Sites
3 TSS

Location &
Maps

Sequence Map
Chr16:97272165-97306136 bp, - strand
From NCBI annotation of GRCm39
Genome Browsers
Genetic Map
Chromosome 16, 57.47 cM
Mapping Data
4 experiments

Strain
Comparison

SNPs within 2kb
707 from dbSNP Build 142
Strain Annotations
18

Homology

Human Ortholog
FAM3B, FAM3 metabolism regulating signaling molecule B
Vertebrate Orthologs
2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog
FAM3B, FAM3 metabolism regulating signaling molecule B
Synonyms
2-21, C21orf11, C21orf76, ORF9, PANDER, PRED44
Links
Chr Location
21q22.3; chr21:41304212-41357727 (+) GRCh38

MGI Vertebrate Homology
HCOP
vertebrate homology predictions:FAM3B
Gene Tree

Human Diseases

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References
3 with disease annotations

Mutations,
Alleles, and
Phenotypes

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Phenotype Summary
8 phenotypes from 2 alleles in 2 genetic backgrounds
50 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles
Endonuclease-mediated
Targeted
Genomic Mutations
6 involving Fam3b
Incidental Mutations
Find Mice (IMSR)
Comparison Matrix

Mice homozygous for a deletion of this gene display elevated blood glucose in glucose tolerance tests and elevated blood insulin after glucose injection, probably due to impaired insulin clearance.

Gene Ontology
(GO)
Classifications

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All GO Annotations
GO References

Molecular Function carbohydrate derivative binding cytoskeletal protein binding DNA binding enzyme regulator hydrolase ligase lipid binding oxidoreductase RNA binding signaling receptor activity signaling receptor binding transcription transferase transporter Biological Process carbohydrate derivative metabolism cell differentiation cell population proliferation cellular component organization DNA-templated transcription establishment of localization homeostatic process immune system process lipid metabolic process programmed cell death protein metabolic process response to stimulus signaling system development Cellular Component cell projection cytoplasmic vesicle cytoskeleton cytosol endoplasmic reticulum endosome extracellular region Golgi apparatus mitochondrion membraneless organelle nucleus organelle envelope organelle lumen plasma membrane protein-containing complex synapse vacuole Click cells to view annotations.

Expression

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results
Tissues
cDNA Data
Literature Summary
Other Mouse Links
Other Vertebrate Links

Sequences &
Gene Models

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All Sequences
RefSeq
UniProt
CCDS
Ensembl
NCBI Gene

Protein
Information

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UniProt
4 Sequences
Protein Ontology
PDB
InterPro Domains
GlyGen

Molecular
Reagents

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All nucleic 9
cDNA 7
Primer pair 2
Microarray probesets 4

References

Summaries
Developmental Gene Expression 2
Diseases 3
Gene Ontology 8
Phenotypes 50
Earliest
J:50129 Cabin DE, et al., Physical and comparative mapping of distal mouse chromosome 16. 5 p5. Genome Res. 1998 Sep;8(9):940-50
Latest
J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;