Chrd MGI Mouse Gene Detail - MGI:1313268 (original) (raw)
Summary
Symbol
ChrdName
chordinSynonyms
ChdFeature Type
protein coding geneIDs
MGI:1313268
NCBI Gene:12667Alliance
Transcription Start Sites
3 TSS
Location &
Maps
more
Sequence Map
Chr16:20551877-20561134 bp, + strand
From Ensembl annotation of GRCm39Genome Browsers
Genetic Map
Chromosome 16, 12.51 cMMapping Data
3 experiments
Strain
Comparison
more
- SNPs within 2kb
218 from dbSNP Build 142 - Strain Annotations
18 - RFLP
Homology
more
Human Ortholog
CHRD, chordinVertebrate Orthologs
3
Vertebrate Orthology Source
Alliance of Genome Resources
- Human Ortholog
CHRD, chordin - Links
- Chr Location
3q27.1; chr3:184380054-184390739 (+) GRCh38
- MGI Vertebrate Homology
- HCOP
vertebrate homology predictions:CHRD - Protein SuperFamily
- Gene Tree
Human Diseases
more
Diseases
2 with Chrd mouse modelsMutations/Alleles
1 with disease annotationsReferences
2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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- Phenotype Summary
100 phenotypes from 2 alleles in 6 genetic backgrounds
40 phenotypes from multigenic genotypes
3 images
17 phenotype references
Phenotype Overview
Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
Click cells to view annotations.
- All Mutations and Alleles
- Targeted
- Incidental Mutations
- Find Mice (IMSR)
- Comparison Matrix
Homozygotes for a targeted null mutation show some death prior to embryonic day 8.5, but most die perinatally with abnormalities of the skull, malformations of cervical and thoracic vertebrae, cardiovascular defects, and absence of parathyroid and thymus.
Gene Ontology
(GO)
Classifications
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- All GO Annotations
- GO References
Expression
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Expression Overview
Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
- Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).
Click cells to view annotations.
Assay Results
Tissues
cDNA Data
Literature Summary
Other Mouse Links
Other Vertebrate Links
Sequences &
Gene Models
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All Sequences
RefSeq
UniProt
CCDS
Ensembl
NCBI Gene
Protein
Information
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- UniProt
7 Sequences - Protein Ontology
- InterPro Domains
IPR052278 Chordin-like dorsalizing regulators - GlyGen
Molecular
Reagents
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References
more
- Summaries
Developmental Gene Expression 75
Diseases 2
Gene Ontology 16
Phenotypes 17 - Earliest
J:46641 Rhinn M, et al., Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification. Development. 1998 Mar;125(5):845-56 - Latest
J:335088 Escuin S, et al., Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouse. Dis Model Mech. 2023 Mar 1;16(3)