Kdm2b MGI Mouse Gene Detail - MGI:1354737 (original) (raw)

Summary

Symbol
Kdm2b
Name
lysine (K)-specific demethylase 2B
Synonyms
Cxxc2, Fbxl10, Jhdm1b, mKIAA3014
Feature Type
protein coding gene
IDs
MGI:1354737
NCBI Gene:30841
Alliance
Transcription Start Sites
25 TSS

Location &
Maps

Sequence Map
Chr5:123008727-123127333 bp, - strand
From NCBI annotation of GRCm39
Genome Browsers
Genetic Map
Chromosome 5, 62.63 cM, cytoband F
Mapping Data
1 experiment

Strain
Comparison

SNPs within 2kb
3465 from dbSNP Build 142
Strain Annotations
18

Homology

Human Ortholog
KDM2B, lysine demethylase 2B
Vertebrate Orthologs
4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog
KDM2B, lysine demethylase 2B
Synonyms
CXXC2, Fbl10, FBXL10, JHDM1B, PCCX2
Links
Chr Location
12q24.31; chr12:121408461-121582279 (-) GRCh38

MGI Vertebrate Homology
HCOP
vertebrate homology predictions:KDM2B
Gene Tree

Mutations,
Alleles, and
Phenotypes

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Phenotype Summary
25 phenotypes from 2 alleles in 2 genetic backgrounds
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles
Chemically induced (other)
Endonuclease-mediated
Gene trapped
Radiation induced
Targeted
Genomic Mutations
2 involving Kdm2b
Incidental Mutations
Find Mice (IMSR)
Comparison Matrix
Recombinase Activity

Mice homozygous for a targeted allele that does not express the long form protein exhibit exencephaly, fetal and postnatal lethality, coloboma, curly tail, oligozoospermia, increased apoptosis, and increased neuronal precursor proliferation.

Gene Ontology
(GO)
Classifications

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All GO Annotations
GO References

Molecular Function carbohydrate derivative binding cytoskeletal protein binding DNA binding enzyme regulator hydrolase ligase lipid binding oxidoreductase RNA binding signaling receptor activity signaling receptor binding transcription transferase transporter Biological Process carbohydrate derivative metabolism cell differentiation cell population proliferation cellular component organization DNA-templated transcription establishment of localization homeostatic process immune system process lipid metabolic process programmed cell death protein metabolic process response to stimulus signaling system development Cellular Component cell projection cytoplasmic vesicle cytoskeleton cytosol endoplasmic reticulum endosome extracellular region Golgi apparatus mitochondrion membraneless organelle nucleus organelle envelope organelle lumen plasma membrane protein-containing complex synapse vacuole Click cells to view annotations.

Expression

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results
Tissues
cDNA Data
Literature Summary
Other Mouse Links
Other Vertebrate Links

Sequences &
Gene Models

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All Sequences
RefSeq
UniProt
CCDS
Ensembl
NCBI Gene

Protein
Information

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UniProt
8 Sequences
Protein Ontology
EC
InterPro Domains
IPR006553 Leucine-rich repeat, cysteine-containing subtype
IPR032675 Leucine-rich repeat domain superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-type
GlyGen

Molecular
Reagents

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All nucleic 19
Primer pair 2
Microarray probesets 3

References

Summaries
Developmental Gene Expression 14
Gene Ontology 14
Phenotypes 30
Earliest
J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest
J:372344 Kondo T, et al., SKP1A bound to Polycomb-silenced genes mediates degradation of PRC2 and preconditions their activation. Mol Cell. 2025 Sep 4;85(17):3306-3320.e6