Ccno MGI Mouse Gene Detail - MGI:2145534 (original) (raw)

Summary

Symbol
Ccno
Name
cyclin O
Synonyms
Ccnu, Ung2
Feature Type
protein coding gene
IDs
MGI:2145534
NCBI Gene:218630
Alliance
Transcription Start Sites
2 TSS

Location &
Maps

Sequence Map
Chr13:113124363-113127313 bp, + strand
From NCBI annotation of GRCm39
Genome Browsers
Genetic Map
Chromosome 13, 63.93 cM
Mapping Data
1 experiment

Strain
Comparison

SNPs within 2kb
193 from dbSNP Build 142
Strain Annotations
18

Homology

Human Ortholog
CCNO, cyclin O
Vertebrate Orthologs
2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog
CCNO, cyclin O
Synonyms
CCNU, CILD29, UDG2
Links
Chr Location
5q11.2; chr5:55231152-55233608 (-) GRCh38

MGI Vertebrate Homology
HCOP
vertebrate homology predictions:CCNO
Gene Tree

Human Diseases

Diseases
1 with human CCNO associations

Mutations,
Alleles, and
Phenotypes

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Phenotype Summary
13 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles
Endonuclease-mediated
Gene trapped
Targeted
Incidental Mutations
Find Mice (IMSR)
Comparison Matrix

Mice homozygous for a knock-out allele exhibit pre-weaning lethality after E17, hydrocephaly, growth retardation, enlarged brain ventricles, thin cerebral cortex, nasal cavity congestion and impaired formation of deuterosomes and centrioles.

Gene Ontology
(GO)
Classifications

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All GO Annotations
GO References

Molecular Function carbohydrate derivative binding cytoskeletal protein binding DNA binding enzyme regulator hydrolase ligase lipid binding oxidoreductase RNA binding signaling receptor activity signaling receptor binding transcription transferase transporter Biological Process carbohydrate derivative metabolism cell differentiation cell population proliferation cellular component organization DNA-templated transcription establishment of localization homeostatic process immune system process lipid metabolic process programmed cell death protein metabolic process response to stimulus signaling system development Cellular Component cell projection cytoplasmic vesicle cytoskeleton cytosol endoplasmic reticulum endosome extracellular region Golgi apparatus mitochondrion membraneless organelle nucleus organelle envelope organelle lumen plasma membrane protein-containing complex synapse vacuole Click cells to view annotations.

Expression

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results
Tissues
cDNA Data
Literature Summary
Other Mouse Links
Other Vertebrate Links

Sequences &
Gene Models

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All Sequences
RefSeq
UniProt
CCDS
Ensembl
NCBI Gene

Protein
Information

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UniProt
2 Sequences
Protein Ontology
InterPro Domains

Molecular
Reagents

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All nucleic 16
Microarray probesets 3

References

Summaries
Developmental Gene Expression 7
Gene Ontology 6
Phenotypes 13
Earliest
J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest
J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136