Cd3g MGI Mouse Gene Detail - MGI:88333 (original) (raw)

Summary

Symbol
Cd3g
Name
CD3 antigen, gamma polypeptide
Synonyms
Ctg-3, Ctg3, T3g
Feature Type
protein coding gene
IDs
MGI:88333
NCBI Gene:12502
Alliance
Transcription Start Sites
7 TSS

Location &
Maps

Sequence Map
Chr9:44880870-44891729 bp, - strand
From NCBI annotation of GRCm39
Genome Browsers
Genetic Map
Chromosome 9, 24.84 cM
Mapping Data
8 experiments

Strain
Comparison

SNPs within 2kb
413 from dbSNP Build 142
Strain Annotations
18
RFLP

Homology

Human Ortholog
CD3G, CD3 gamma subunit of T-cell receptor complex
Vertebrate Orthologs
2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog
CD3G, CD3 gamma subunit of T-cell receptor complex
Synonyms
CD3-GAMMA, CD3GAMMA, IMD17, T3G
Links
Chr Location
11q23.3; chr11:118344344-118355161 (+) GRCh38

MGI Vertebrate Homology
HCOP
vertebrate homology predictions:CD3G
Gene Tree

Human Diseases

Diseases
1 with human CD3G associations

Mutations,
Alleles, and
Phenotypes

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Phenotype Summary
14 phenotypes from 3 alleles in 3 genetic backgrounds
4 phenotypes from multigenic genotypes
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles
Endonuclease-mediated
Gene trapped
Targeted
Genomic Mutations
4 involving Cd3g
Incidental Mutations
Find Mice (IMSR)
Comparison Matrix

Mice homozygous for a knock-out allele exhibit decreased thymocyte number and T cell response.

Gene Ontology
(GO)
Classifications

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All GO Annotations
GO References

Molecular Function carbohydrate derivative binding cytoskeletal protein binding DNA binding enzyme regulator hydrolase ligase lipid binding oxidoreductase RNA binding signaling receptor activity signaling receptor binding transcription transferase transporter Biological Process carbohydrate derivative metabolism cell differentiation cell population proliferation cellular component organization DNA-templated transcription establishment of localization homeostatic process immune system process lipid metabolic process programmed cell death protein metabolic process response to stimulus signaling system development Cellular Component cell projection cytoplasmic vesicle cytoskeleton cytosol endoplasmic reticulum endosome extracellular region Golgi apparatus mitochondrion membraneless organelle nucleus organelle envelope organelle lumen plasma membrane protein-containing complex synapse vacuole Click cells to view annotations.

Expression

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results
Tissues
cDNA Data
Literature Summary
Other Mouse Links
Other Vertebrate Links

Sequences &
Gene Models

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All Sequences
RefSeq
UniProt
CCDS
Ensembl
NCBI Gene

Protein
Information

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UniProt
4 Sequences
Protein Ontology
PDB
InterPro Domains
IPR032052 CD3 gamma/delta subunit, Ig-like domain
IPR015484 CD3 protein, epsilon/gamma/delta subunit
IPR036179 Immunoglobulin-like domain superfamily
IPR003110 Phosphorylated immunoreceptor signalling ITAM
GlyGen

Molecular
Reagents

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All nucleic 40
Genomic 9
Primer pair 1
Microarray probesets 3

Other
Accession IDs

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MGD-MRK-14698, MGD-MRK-1854, MGD-MRK-2212, MGD-MRK-2213

References

Summaries
Developmental Gene Expression 5
Gene Ontology 7
Phenotypes 28
Earliest
J:8651 Gold DP, et al., The gene encoding the epsilon subunit of the T3/T-cell receptor complex maps to chromosome 11 in humans and to chromosome 9 in mice. Proc Natl Acad Sci U S A. 1987 Mar;84(6):1664-8
Latest
J:359311 Lin F, et al., Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment. Cell. 2024 Nov 2;