Sfrp4 MGI Mouse Gene Detail - MGI:892010 (original) (raw)

Summary

Symbol
Sfrp4
Name
secreted frizzled-related protein 4
Feature Type
protein coding gene
IDs
MGI:892010
NCBI Gene:20379
Alliance
Transcription Start Sites
3 TSS

Location &
Maps

Sequence Map
Chr13:19807345-19816995 bp, + strand
From NCBI annotation of GRCm39
Genome Browsers
Genetic Map
Chromosome 13, 6.99 cM
Mapping Data
4 experiments

Strain
Comparison

SNPs within 2kb
431 from dbSNP Build 142
Strain Annotations
18
PCR
RFLP

Homology

Human Ortholog
SFRP4, secreted frizzled related protein 4
Vertebrate Orthologs
2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog
SFRP4, secreted frizzled related protein 4
Synonyms
FRP-4, FRPHE, FRZB-2, PYL, sFRP-4
Links
Chr Location
7p14.1; chr7:37905932-38025695 (-) GRCh38

MGI Vertebrate Homology
HCOP
vertebrate homology predictions:SFRP4
Gene Tree

Human Diseases

Diseases
1 with human SFRP4 associations

Mutations,
Alleles, and
Phenotypes

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Phenotype Summary
26 phenotypes from 4 alleles in 3 genetic backgrounds
9 phenotypes from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles
Endonuclease-mediated
Gene trapped
Radiation induced
Targeted
Genomic Mutations
1 involving Sfrp4
Incidental Mutations
Find Mice (IMSR)
Comparison Matrix

Mice homozygous for one null allele exhibit reduced litter size produced from female mice while mice homozygous for another exhibit hyper-fertile female mice and increased litter size. Mice homozygous for a different null allele exhibit increased trabecular bone mass, decreased compact bone thickness, and protection from age-related osteoporosis.

Gene Ontology
(GO)
Classifications

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All GO Annotations
GO References

Molecular Function carbohydrate derivative binding cytoskeletal protein binding DNA binding enzyme regulator hydrolase ligase lipid binding oxidoreductase RNA binding signaling receptor activity signaling receptor binding transcription transferase transporter Biological Process carbohydrate derivative metabolism cell differentiation cell population proliferation cellular component organization DNA-templated transcription establishment of localization homeostatic process immune system process lipid metabolic process programmed cell death protein metabolic process response to stimulus signaling system development Cellular Component cell projection cytoplasmic vesicle cytoskeleton cytosol endoplasmic reticulum endosome extracellular region Golgi apparatus mitochondrion membraneless organelle nucleus organelle envelope organelle lumen plasma membrane protein-containing complex synapse vacuole Click cells to view annotations.

Expression

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results
Tissues
cDNA Data
Literature Summary
Other Mouse Links
Other Vertebrate Links

Sequences &
Gene Models

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All Sequences
RefSeq
UniProt
CCDS
Ensembl
NCBI Gene

Protein
Information

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UniProt
4 Sequences
Protein Ontology
InterPro Domains
IPR036790 Frizzled cysteine-rich domain superfamily
IPR015526 Frizzled/secreted frizzled-related protein
IPR018933 Netrin module, non-TIMP type
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
GlyGen
Q9Z1N6 5 sites, 3 N-linked glycans (3 sites)

Molecular
Reagents

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All nucleic 38
Genomic 1
Primer pair 8
Other 5
Microarray probesets 3

References

Summaries
Developmental Gene Expression 32
Gene Ontology 5
Phenotypes 18
Earliest
J:39275 Rattner A, et al., A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2859-63
Latest
J:353721 Chen R, et al., Sfrp4 is required to maintain Ctsk-lineage periosteal stem cell niche function. Proc Natl Acad Sci U S A. 2023 Nov 14;120(46):e2312677120