H2-DMb1 MGI Mouse Gene Detail - MGI:95922 (original) (raw)

Summary

Symbol
H2-DMb1
Name
histocompatibility 2, class II, locus Mb1
Synonyms
H2-Mb1, H-2Mb1, H2-M beta1
Feature Type
protein coding gene
IDs
MGI:95922
NCBI Gene:14999
Alliance
Transcription Start Sites
3 TSS

Location &
Maps

Sequence Map
Chr17:34372165-34379203 bp, + strand
From NCBI annotation of GRCm39
Genome Browsers
Genetic Map
Chromosome 17, 17.98 cM
Mapping Data
3 experiments

Strain
Comparison

SNPs within 2kb
2 from dbSNP Build 142
Strain Annotations
13

Homology

Human Ortholog
HLA-DMB, major histocompatibility complex, class II, DM beta
Vertebrate Orthologs
2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog
HLA-DMB, major histocompatibility complex, class II, DM beta
Synonyms
D6S221E, RING7
Links
Chr Location
6p21.32; chr6:32934629-32941028 (-) GRCh38

MGI Vertebrate Homology
HCOP
vertebrate homology predictions:HLA-DMB
Gene Tree

Mutations,
Alleles, and
Phenotypes

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Phenotype Summary
2 phenotype references
All Mutations and Alleles
Targeted
Incidental Mutations
Find Mice (IMSR)

Gene Ontology
(GO)
Classifications

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All GO Annotations
GO References

Molecular Function carbohydrate derivative binding cytoskeletal protein binding DNA binding enzyme regulator hydrolase ligase lipid binding oxidoreductase RNA binding signaling receptor activity signaling receptor binding transcription transferase transporter Biological Process carbohydrate derivative metabolism cell differentiation cell population proliferation cellular component organization DNA-templated transcription establishment of localization homeostatic process immune system process lipid metabolic process programmed cell death protein metabolic process response to stimulus signaling system development Cellular Component cell projection cytoplasmic vesicle cytoskeleton cytosol endoplasmic reticulum endosome extracellular region Golgi apparatus mitochondrion membraneless organelle nucleus organelle envelope organelle lumen plasma membrane protein-containing complex synapse vacuole Click cells to view annotations.

Expression

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results
Tissues
cDNA Data
Literature Summary
Other Mouse Links

Sequences &
Gene Models

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All Sequences
RefSeq
UniProt
CCDS
Ensembl
NCBI Gene

Protein
Information

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UniProt
16 Sequences
Protein Ontology
PR:000034662 class II histocompatibility antigen, M beta 1 chain
InterPro Domains
IPR036179 Immunoglobulin-like domain superfamily
IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
IPR050160 Major Histocompatibility Complex/Immunoglobulin
IPR011162 MHC classes I/II-like antigen recognition protein
IPR014745 MHC class II, alpha/beta chain, N-terminal
IPR000353 MHC class II, beta chain, N-terminal
GlyGen

Molecular
Reagents

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All nucleic 63
Genomic 5
Primer pair 3
Other 1
Microarray probesets 3

Other
Accession IDs

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MGD-MRK-10406, MGD-MRK-10518, MGI:2146833

References

Summaries
Developmental Gene Expression 2
Gene Ontology 6
Phenotypes 2
Earliest
J:11259 Cho S, et al., A cluster of transcribed sequences between the Pb and Ob genes of the murine major histocompatibility complex. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5197-201
Latest
J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42