Journal of Neuroscience (original) (raw)

The Journal of Neuroscience: 44 (39)

About the Cover

This confocal image of a lesion in the corpus callosum shows zinc finger protein (ZFP488)-expressing oligodendrocytes (green), astrocytes (cyan), and microglia (red). ZFP488 is a transcriptional regulator enriched in oligodendrocytes. Siying Cui and colleagues generated a ZFP488 knockout mouse model to explore in vivo genetic requirements for ZFP488 during oligodendrocyte development and remyelination following injury. ZFP488 loss delayed myelination and impaired remyelination without affecting astrocyte or microglia populations. See the article by Cui et al. for more information on the mechanism they uncovered. Cover image: Fangbing Chen.