Diarylquinolines target subunit c of mycobacterial ATP synthase (original) (raw)

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Acknowledgements

We thank P. Janssens, T. Gevers, H. Szel, J. Hendrickx, A. Shanmugham, E. Pasquier, A. Poncelet, P. Palandjian, S. Masure, W. Bruinzeel and P. Verhasselt for technical help; N. Lounis, L. Geeraert and M. Haxaire-Theeuwes for critical reading; E. Mortz (Alphalyse, Denmark) for mass spectrometry analysis; H. Van Vlijmen for R207910-docking figure; L. Leijssen for help with figures; and Vichem (Budapest) for coupling experiments. Z.R., H.L. and D.B. acknowledge EU financial support (Marie-Curie MRTN-CT-2005-019481).

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Author notes

  1. Anil Koul and Najoua Dendouga: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Antimicrobial Research, Tibotec BVBA, Johnson & Johnson, Turnhoutseweg 30, Beerse, B-2340, Belgium
    Anil Koul, Najoua Dendouga, Karen Vergauwen, Brenda Molenberghs, Luc Vranckx, Rudy Willebrords & Koen Andries
  2. Department of Structural Biology, Institute of Molecular Cell Biology, Vrije Universiteit Amsterdam, De Boelelaan 1085, Amsterdam, 1081HV, The Netherlands
    Zorica Ristic, Holger Lill & Dirk Bald
  3. Pharmaceutical Research & Development, Johnson & Johnson, Campus de Maigremont-BP615, Val de Reuil Cedex, F-27106, France
    Ismet Dorange & Jerome Guillemont

Authors

  1. Anil Koul
  2. Najoua Dendouga
  3. Karen Vergauwen
  4. Brenda Molenberghs
  5. Luc Vranckx
  6. Rudy Willebrords
  7. Zorica Ristic
  8. Holger Lill
  9. Ismet Dorange
  10. Jerome Guillemont
  11. Dirk Bald
  12. Koen Andries

Contributions

A.K. wrote the manuscript as a project team leader, with contributions from K.A., D.B. and N.D. A.K., K.A., N.D. and D.B. contributed to study design and data analysis. K.V. did ATP synthesis assay; N.D. made constructs for subunit c purification; N.D. and B.M. did affinity chromatography assays and complementation studies; R.W. contributed to DARQ screening; L.V. did ATP measurements, MIC determinations and isolation of resistant mutants; J.G. and I.D. synthesized DARQs, separated isomers and performed chemical characterizations; and H.L. and Z.R. contributed to the BIAcore binding experiments.

Corresponding author

Correspondence toAnil Koul.

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Competing interests

Research for this project is mainly provided by Johnson & Johnson Pharmaceuticals. A.K., N.D., K.V., B.M., L.V., R.W., I.D., J.G and K.A. are employees of Johnson & Johnson.

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Koul, A., Dendouga, N., Vergauwen, K. et al. Diarylquinolines target subunit c of mycobacterial ATP synthase.Nat Chem Biol 3, 323–324 (2007). https://doi.org/10.1038/nchembio884

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