Nature Medicine (original) (raw)

A butterfly-shaped area of weeds and pests, which represent autoreactive B cells and plasma cells, being cleared by tractors and pesticide sprayers, which represent the two types of CAR T cells.

When politics trumps patients

Elected to make America healthy again, the actions of the Trump administration have undermined health globally.

Year in Review 05 December 2025

Advancing equitable and sustainable urban health

Cities are often at the forefront of creative thinking on policy opportunities; this Perspective outlines an agenda for urban health research that promotes a virtuous cycle by which population health and environmental sustainability support and reinforce each other.

Determining the value of genomics in healthcare

Assessing the value of genomics is key to informing evidence-based policies; this Review outlines how current approaches to health technology assessment, implementation and data management can be adapted to suit the rapidly evolving technology and evidence base.

Announcements

30th Anniversary Series on the Future of Medicine

As Nature Medicine celebrates the 30th anniversary of its launch, we reflect on what the future holds for medicine and for our journal. In this Series, we spotlight key challenges and opportunities as we look to the next 30 years of biomedical innovation.

Series: Women’s health throughout the lifecourse

Women’s health has been underfunded and underprioritized for too long, leading to delays in diagnosis and poor health outcomes. This series will bring together a range of viewpoints and new research focusing on the causes of ill health in women and the barriers to their health and wellbeing in the 21st Century.

Diversity, equity and inclusion in medical research

This ongoing series brings together a range of viewpoints on DEI in medical research, covering topics such as funding biases, workforce diversity and how to fix the lack of diversity of health data. Reach out to us to contribute your perspective.

Latest Research articles

Targeting of HIF2-driven cachexia in kidney cancer

In vivo experiments and clinical cohort analyses show that hypoxia-inducible factor 2 (HIF2)-induced parathyroid hormone-related protein (PTHrP) expression contributes to cachexia in the context of renal cell carcinoma (RCC). The pathway can be targeted by HIF2 inhibitors, including belzutifan, which may reduce cachexia in patients with RCC.

A therapeutic peptide vaccine for fibrolamellar hepatocellular carcinoma: a phase 1 trial

In this phase 1 trial, treatment of patients with fibrolamellar hepatocellular carcinoma with a therapeutic peptide vaccine targeting the fusion kinase DNAJB1–PRKACA, which is the driver of the disease, together with nivolumab and ipilimumab, was safe and led to encouraging preliminary clinical responses, and translational analysis showed activation of immune responses.

Latest Reviews & Analysis

Nature Careers