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Lifetime risk and projected burden of dementia
A cohort study of over 15,000 US adults found that the lifetime risk of developing dementia from ages 55 to 95 is 42%, with the highest risk in APOE _ε_4 carriers, women and Black adults, and projected that approximately 1 million US adults will develop dementia annually by 2060.
Brief Communication13 Jan 2025
Setting sights on a single-shot malaria vaccine
In a game-changing development for malaria vaccines, single-dose immunization with a genetically weakened whole malaria parasite vaccine achieved an unprecedented 90% protection.
- Debashree Goswami
- Stefan H. I. Kappe
News & Views03 Jan 2025
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Genomic reanalysis of a pan-European rare-disease resource yields new diagnoses
This flagship study from the European Solve-Rare Diseases Consortium presents a diagnostic framework including bioinformatic analysis of clinical, pedigree and genomic data coupled with expert panel review, leading to 500 new diagnoses in a cohort of 6,000 families with suspected rare diseases.
- Steven Laurie
- Wouter Steyaert
- Alexander Hoischen
ArticleOpen Access17 Jan 2025 - ArticleOpen Access14 Jan 2025
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Latest Reviews & Analysis
Clinically useful obesity subtypes revealed by harnessing deviations from population-average risk
Obesity is associated with many life-threatening comorbidities. Its heterogeneous risk profile makes the prevention of obesity and its pathogenic consequences challenging. In this study, the heterogeneous relationships between body mass index and ten cardiovascular risk markers were quantified using machine learning, from which powerful clinical prediction models were developed and validated.
Differences in the lifetime risk and population burden of dementia
Dementia is a major public health burden, and determining its lifetime risk is essential to inform prevention strategies. In a large cohort study of adults, 42% of participants ≥55 years of age developed dementia by age 95. Lifetime dementia risk was highest among women and Black adults, highlighting the importance of addressing underlying inequalities.
Visualizing the effects and causes of caregiver deaths on children in the USA
Death of caregivers threaten child wellbeing. We estimate that 2.91 million children and adolescents in the USA had experienced death of a caregiver between 2000 and 2021. We describe the drivers of orphanhood and identify populations that are disproportionately affected. Our findings may inform policies and programs that address caregiver loss and its consequences.
Not all _KRAS-_mutated pancreatic cancers are equal — mutant dosage matters
KRAS mutations are ubiquitous in pancreatic adenocarcinomas (PDACs) and are associated with poor outcomes. We leveraged a cohort of 2,336 PDAC tumors to characterize genomic subtypes and their prognostic correlates across clinical stages. A key finding is that shallow copy gains in KRAS mutant alleles are common and indicate unfavorable prognosis.
The TRIPOD-LLM reporting guideline for studies using large language models
TRIPOD-LLM (transparent reporting of a multivariable model for individual prognosis or diagnosis–large language model) is a checklist of items considered essential for good reporting of studies that are developing or evaluating an LLM for use in healthcare settings. It is a ‘living guideline’ that emphasizes transparency, human oversight and task-specific performance reporting.
