Nature Reviews Nephrology (original) (raw)
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WEBINAR ON Digital Determinants of Health
Watch the recording of our webinar on "Digital Determinants of Health: AI and the need for equity-focused innovation in digital health" with Leo Celi and Kianoush Kashani.
SERIES ON Tools & Technologies
A series of articles that aim to explore the tools and techniques that are improving our understanding of renal development, physiology and disease mechanisms as well as contributing to advances in the screening, diagnosis and management of kidney diseases.
Focus on the Sustainable Development Goals
This Focus issue examines how tackling the three dimensions of sustainable development — social, economic and environmental — is essential to improving global kidney health.
Latest Reviews & Analysis
Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease
Kidney fibrosis is a key pathological process in chronic kidney disease. Here, the authors examine how the metabolic reprogramming of kidney immune and non-immune cells in response to injury can promote fibrosis and consider the potential of metabolism-targeted therapies for preventing the development and progression of kidney fibrosis.
Polygenic scores and their applications in kidney disease
Polygenic scores model the combined risk of multiple variants across the genome to identify individuals at inherited risk of complex diseases. This Review discusses evolving methods for developing polygenic scores and describes examples across a spectrum of disease traits.
The pathogenesis of IgA nephropathy and implications for treatment
IgA nephropathy (IgAN) is thought to result from multiple hits that culminate in immune complex deposition in the kidney. Here, the authors describe the latest insights into the pathogenesis of IgAN and how they have revealed novel therapeutic targets and approaches to this disease.
Amino acid metabolism in kidney health and disease
The kidney has an important role in the handling of amino acids, facilitated by a complex network of kidney transporters and enzymes. This Review provides an overview of the role of the kidney in the synthesis, degradation, filtration, reabsorption and excretion of different amino acids and the relevance of these functions in the context of kidney physiology and disease.
