Gene delivery - Latest research and news (original) (raw)

Gene delivery articles from across Nature Portfolio

Gene delivery is a process by which foreign DNA is transferred to host cells for applications such as genetic research or gene therapy. Gene delivery methods can be mechanical (e.g. microinjection, electroporation or biolistics), chemical (e.g. lipid or nanoparticle carriers) or biological (e.g. viral or bacterial vectors).

A tunable gene therapy for heart regeneration

AAV-based gene therapies hold promise for treating disease, but their long-lasting gene expression limits their use in regenerative medicine. A study now presents DreAM, a drug-inducible AAV system that enables tunable tissue-specific gene activation via the splicing modulator risdiplam, and its potential application in myocardial infarction.

Latest Research and Reviews

Combined treatment using bismuth sulfide nanoparticles loaded with NANOG decoy oligodeoxynucleotides under X-ray radiation for breast cancer cells

Evaluation of transduction efficiency in pancreatic beta and alpha cells utilizing various AAV serotypes

Induction of flowering in Arabidopsis through functional peptide-mediated FT mRNA delivery

Effective treatment of systemic candidiasis by synergistic targeting of cell wall synthesis

In this work, authors generate nanoconstructs that synergistically target cell wall synthesis in Candida pathogens, which induce potent antifungal effects and prolonged survival in candidiasis, providing an alternative treatment option to conventional drugs.

Transgene- and tissue culture-free heritable genome editing using RNA virus-based delivery in wheat

Efficient delivery systems are urgently needed for genome editing in monocot plants. Here, this study develops a system of virus-induced genome editing in tillers (ViGET) to achieve heritable editing in wheat bypassing transgene and tissue culture.

AAV for ovarian cancer gene therapy

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News and Comment

A tunable gene therapy for heart regeneration

AAV-based gene therapies hold promise for treating disease, but their long-lasting gene expression limits their use in regenerative medicine. A study now presents DreAM, a drug-inducible AAV system that enables tunable tissue-specific gene activation via the splicing modulator risdiplam, and its potential application in myocardial infarction.

Improving the safety of lipid nanoparticle-based DNA delivery for extended gene expression

DNA delivery using lipid nanoparticles results in severe toxicity in mice. However, we find that the incorporation of endogenous anti-inflammatory lipids into the lipid nanoparticles mitigates this toxicity and enables prolonged gene expression.
News & Views03 Mar 2025 Nature Biotechnology
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A preprint by Xu et al. shows that MHC-pseudotyped retroviruses can reprogramme, activate and expand tumour-specific T cell populations in vivo.

Lysozyme-coated LDHs boost trait control

Coating RNA- or DNA-loaded layered double hydroxide nanosheets with lysozyme enhances their uptake by loosening the plant cell wall and stimulating endocytosis and membrane trafficking — with promising implications for both fundamental research and agricultural applications.

Therapeutic interfering particles against HIV: molecular parasites reducing viremia

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