Human BAC Resource (original) (raw)

Figure 1b.

Clones selected on the basis of band location were used in FISH analysis to map the breakpoint of a translocation involving chromosomes 11 and 19 in a patient with multiple congenital malformations and mental retardation (DGAP012, http://dgap.harvard.edu). Clone CTD-3193o13 spans the breakpoint on chromosome 19; red signal is split between the derivative chromosome 11 and derivative 19 chromosomes and is also present on the normal chromosome 19. The GTG-banded karyotype for this patient is 46,X,Y,t(11;19)(p11.2;p13.3).

The BAC Resource Consortium

V.G.Cheung1*, N.Nowak2*, W.Jang3, I.R.Kirsch4, S.Zhao5, X.-N.Chen6, T.S.Furey10, U.-J.Kim7%, W.-L.Kuo8, M.Olivier9, J.Conroy2, A.Kasprzyk11, H.Massa12, R.Yonescu4, S.Salt2, C.Thoreen13%, A.Snijders8, E.Lemyre14, J.A.Bailey15, A.Bruzel1, W.D.Burill11, S.M.Clegg11, S.Collins13, P.Dhami11, C.Friedman12, C.S.Han16, S.Herrick14, J.Lee7, A.H.Ligon14, S.Lowrey17, M.Mortey1, S.Naraslmban1, K.Osoegawa18, Z.Peng17, I.Plajzer-Frick17, B.J.Quade14, D.Scott17, K.Sirotkin3, A.A.Thorpe11, J.W.Gray8, J.Hudson19, D.Pinkel8, T.Ried4, L.Rowen20, G.L.Shen-Ong4%, R.I.Strausberg4, E.Birney11, D.F.Callen21, J.-F.Cheng17, D.R.Cox9, N.A.Doggett16, N.P.Carter11, E.E.Eichler15, D.Haussler10, J.R.Korenberg6, C.C.Morton14, D.Albertson8, G.Schuler3, P. de Jong18, and B.J.Trask12

* equal contributions

Addresses:
1, Department of Pediatrics, University of Pennsylvania, The Children's Hospital of Philadelphia, 3516 Civic Center Blvd., ARC 516, Philadelphia PA 19104;

2, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo NY 14263;

3, National Center for Biotechnology Information, National Library of Medicine, Building 38A/Room 8N805, Bethesda MD 20894;

4, National Cancer Institute, NIH, Building 10/Room 12N214, Bethesda MD 20889-5105;

5, The Institute for Genomic Research, 9712 Medical Center Drive, Rockville MD 20850;

6, Departments of Pediatrics and Human Genetics, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles CA 90048;

7, Department of Biology, California Institute of Technology, Mail Code 147-75, Pasadena CA 91125;

8, University of California San Francisco Cancer Center, Box 0808, San Francisco CA 94143-0808;

9, Stanford University, Genome Lab, Mail Code 5120, Stanford CA 94305-5120;

10, Computer Science Department, University of California Santa Cruz, 1156 High Street, Santa Cruz CA 95064-1077;

11, Sanger Center, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK;

12, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North C3-168, P.O. Box 19024, Seattle WA 98109-1024;

13, Department of Molecular Biotechnology, University of Washington, Box 357730, Seattle WA 98195-7730;

14, Departments of Obstetrics and Gynecology and Pathology, Brigham and Women's Hospital, Amory Lab Building 3rd floor, Boston MA 02115;

15, Department of Human Genetics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland OH 44106;

16, Joint Genome Institute-Los Alamos National Laboratory, MS M888 B-N1, P.O. Box 1663, Los Alamos NM 87545;

17, Joint Genome Institute-Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mail Stop 84-171, Berkeley CA 94720;

18, Children's Hospital Oakland Research Institute, 747 52nd Street, Oakland CA 94609;

19, Research Genetics, 2130 Memorial Parkway, Huntsville AL 35801;

20, Institute for Systems Biology, 4225 Roosevelt Way NE, Suite 200, Seattle WA 98105-6099;

21, Department of Cytogenetics and Molecular Genetics, Women's and Children's Hospital, 72 King William Road, North Adelaide, South Australia 5006, Australia;

%Present addresses:

PanGenomics, 6401 Foothill Boulevard, Tujunga CA 91024 (U.-J. Kim);

Harvard Medical School, 240 Longwood Avenue, Cell Biology, Cambridge MA 02115 (C. Thoreen);

Gene Logic, Inc., 708 Quince Orchard Road, Gaithersburg MD 20878 (G. L. Shen-Ong).

Correspondence should be addressed to B.J.T. (e-mail: btrask@fhcrc.org).