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NIH Director's Blog NOV. 14, 2024
Discovery of Culprit Behind Scars in Heart Failure Points to Possible Treatment Target
More than 6 million adults in the U.S. have heart failure, a condition that develops when the heart can’t pump enough blood to meet the demands of the body. While lifestyle changes and treatment can slow heart failure, there’s no cure. One reason is that heart failure and other heart conditions including heart attacks lead heart muscle to become thickened and scarred in a process known as fibrosis. Effective strategies to reverse or stop fibrosis in the heart or other organs after injury, as is needed for recovery, have remained elusive. Now, a new NIH-supported study offers a step forward in better understanding what happens in human heart failure. These findings, reported in Nature, identify a cell type that may be a main culprit in the formation of scar tissue after heart injury. What’s even more encouraging is that the study, which included mouse models, suggests that existing treatments that block communication between the immune system and the scar-forming cells may hold promise for limiting fibrosis to improve heart function.
NCBI Insights NOV. 14, 2024
RefSeq Release 227 is Available!
Check out RefSeq release 227, now available online and from the FTP site. You can access RefSeq data through NCBI Datasets. The release is provided in several directories as a complete dataset and also as divided by logical groupings. What’s included in this release? As of November 4, 2024, this full release incorporates genomic, transcript, and protein data containing: … Continue reading RefSeq Release 227 is Available! →